玫瑰痤疮治疗新进展  

New advances on the treatment of rosacea

作　　者：李嘉 肖树朋 王宇 LI Jia;XIAO Shupeng;WANG Yu(Southern Medical University,Guangzhou 510091,China)

机构地区：[1]南方医科大学皮肤病医院,广东广州510091

出　　处：《皮肤性病诊疗学杂志》2024年第10期710-715,共6页Journal of Diagnosis and Therapy on Dermato-venereology

基　　金：广东省医学科学技术研究基金(B2023394)。

摘　　要：玫瑰痤疮是一种慢性炎症性皮肤病,其特征包括阵发性潮红、持久性红斑、丘疹、脓疱、毛细血管扩张等。玫瑰痤疮发病机制复杂,传统疗法虽已被证实可改善患者症状,但其疗效并不理想。近年来针对玫瑰痤疮的治疗,国内外学者不断提出新的思路,在局部注射、系统药物、物理治疗等领域皆有新进展。肉毒杆菌毒素(BTX)注射可改善患者面部红斑、潮红并提升患者生活质量。原本用于治疗其他疾病的药物,如氨甲环酸和二甲双胍等,亦被发现对玫瑰痤疮具有潜在疗效。此外,针对玫瑰痤疮患者所合并的神经精神系统或消化系统疾病进行治疗,也可缓解患者的皮肤病变。本文综述近年来玫瑰痤疮治疗的新进展,旨在为临床治疗提供新思路。Rosacea is a chronic inflammatory skin disease,characterized by transient flushing,persistent erythema,papules,pustules and telangiectasia.The pathogenesis of rosacea is complex.Although traditional therapies have been shown to improve the symptoms,the therapeutic effect is not satisfactory.In recent years,scholars at home and abroad have proposed new therapeutic approaches to treat rosacea and advancement has been achieved in the fields of topical injection therapy,systemic therapy and physical therapy.Injections of botulinum toxin(BTX)can improve the facial erythema and flushing as well as patients quality of life.Medications such as Tranexamic Acid(TXA)and metformin originally prescribed for other disorders have shown potential therapeutic effects on rosacea.Additionally,the treatment of either neurological or psychiatric disorders or digestive diseases that are comorbid with rosacea may also alleviate rosacea.This article reviews the recent advances in the treatment of rosacea,aiming to provide new insights for the clinical treatment.

关 键 词：玫瑰痤疮 局部注射 系统药物治疗 物理治疗 肉毒杆菌毒素 

分 类 号：R758.734[医药卫生—皮肤病学与性病学]