心脏X综合征患者中性粒细胞/淋巴细胞比值与MR心肌首过灌注相关研究  

Association Between Neutrophil-to-Lymphocyte Ratio and MR Myocardial First Pass Perfusion in Patients with Cardiac Syndrome X

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作  者:张刚[1] 贺俊景 孙杰梅 周丽格 邢威[1] ZHANG Gang;HE Junjing;SUN Jiemei;ZHOU Lige;XING Wei(Department of Magnetic Resonance,The First Affiliated Hospital of Henan University of Traditional Chinese Medicine)

机构地区:[1]河南中医药大学第一附属医院磁共振室

出  处:《中国医学计算机成像杂志》2024年第5期556-561,共6页Chinese Computed Medical Imaging

基  金:河南省中医药科学研究专项课题(2021JDZY023)。

摘  要:目的:探索心脏X综合征(CSX)患者磁共振心肌首过灌注指标均值和变异系数与血液中性粒细胞/淋巴细胞比值(NLR)的相关性。方法:53例CSX患者和43例不稳定型心绞痛(UAP)患者均行静息态磁共振心肌首过灌注检查和血常规检查。分析左心室16个节段心肌灌注参数[包括灌注指数、斜率/基线信号强度(CPI)、峰值时间、20%~80%峰值时间、最大信号强度/基线信号强度(MaxSIBL)],及16个节段的均值和变异系数,比较心肌灌注参数及血液NLR的组间差异,并分析两者的相关性。结果:与UAP组比较,CSX组心肌各节段灌注参数和均值没有差异,但16节段的20%~80%峰值时间变异系数和MaxSIBL变异系数较UAP组升高(P<0.05),血液中性粒细胞(N)和NLR也升高(P<0.05),且CSX组的血液NLR值与心肌平均灌注系数负相关。CSX患者16个节段中CPI及MaxSIBL存在显著组间差异。经两两比较,节段1-5、2-4、2-5、2-10、2-11、3-4、3-5、3-10、3-11、5-14、11-14间的CPI及MaxSIBL均存在显著差异,主要是由节段4、5、10和11灌注系数较低所致。结论:本研究发现CSX患者心肌首过灌注指标不均匀性较UAP患者增加,CSX患者心肌灌注系数与血液NLR呈负相关,说明炎症反应在CSX发生发展过程中具有重要意义。Purpose:To investigate the relationship between the blood neutrophil-to-lymphocyte ratio(NLR)and the mean value and coefficient of variation of the magnetic resonance myocardial first pass perfusion parameters in patients with cardiac syndrome X(CSX).Methods:A total of 53 patients diagnosed with CSX and 43 patients diagnosed with unstable angina pectoris(UAP)were evaluated using rest magnetic resonance myocardial perfusion examination and blood routine examination.The analysis involved the examination of myocardial perfusion parameters,including the perfusion index,slope/baseline signal intensity(CPI),peak time,20%-80%peak time,and maximum signal intensity/baseline signal intensity(MaxSIBL).Additionally,the mean and coefficient of variation were calculated for each of the 16 segments of the left ventricle.Intergroup differences in myocardial perfusion parameters and blood NLR were explored,and the correlations between these variables were analyzed.Results:Compared with the UAP group,there was no difference in the perfusion parameters and mean values of each segment of the CSX group's myocardium.However,the 20%-80%peak time coefficient of variation and the MaxSIBL coefficient of variation of the 16 segments were higher in the CSX group than those in the UAP group(P<0.05).Blood neutrophils(N)and NLR were also higher(P<0.05),and the blood NLR value in the CSX group was negatively correlated with the mean myocardial perfusion coefficient.There were significant intergroup differences in CPI and MaxSIBL among the sixteen segments of CSX patients.After pairwise comparison,there were significant differences in CPI and MaxSIBL between segments 1-5,2-4,2-5,2-10,2-11,3-4,3-5,3-10,3-11,5-14,and 11-14,mainly due to the lower perfusion coefficients in segments 4,5,10,and 11.Conclusions:This study revealsed that the heterogeneity of myocardial first-pass perfusion indices was greater in CSX patients when compared to UAP patients.Additionally,a negative correlation was observed between the myocardial perfusion index in CSX patie

关 键 词:心脏X综合征 心肌灌注 磁共振 中性粒细胞/淋巴细胞比值 

分 类 号:R542.2[医药卫生—心血管疾病] R445.2[医药卫生—内科学]

 

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