Investigation of bioactivity and biodegradability of Mg-bioceramic implants:An in vitro study for biomedical applications  

镁基生物陶瓷植入物的生物活性和生物可降解性研究:生物医学的体外应用

作　　者：ESMAIELZADEH Omar EIVANI Ali Reza MEHDIZADE Maryam TAJALI Nooshin S.H.MOUSAVI ANIJDAN JAFARIAN Hamid Reza 

机构地区：[1]School of Metallurgy and Materials Engineering,Iran University of Science and Technology,Tehran 16846-13114,Iran [2]Department of Mechanical and Industrial Engineering,University of Toronto,Toronto ON M5S 3G8,Canada

出　　处：《Journal of Central South University》2024年第9期2992-3013,共22页中南大学学报（英文版）

摘　　要：In this study,Mg-based composites,by the addition of ZnO,Ca_(2)ZnSi_(2)O_(7),Ca_(2)MgSi_(2)O_(7),and CaSiO_(3)as bioactive agents,were fabricated using friction stir processing.The microstructure and in vitro assessment of bioactivity,biodegradation rate,and corrosion behavior of the resultant composites were investigated in simulated body fluid(SBF).The results showed that during the immersion of composites in SBF for 28 d,due to the release of Ca^(2+)and PO_(4)^(3-)ions,hydroxyapatite(HA)crystals with cauliflower shaped morphology were deposited on the surface of composites,confirming good bioactivity of composites.In addition,due to the uniform distribution of bioceramic powders throughout Mg matrix,grain refinement of the Mg matrix,and uniform redistribution of secondary phase particles,the polarization resistance increased,and the biodegradation rate of composites significantly reduced compared to monolithic Mg matrix.The polarization corrosion resistance of Mg-ZnO increased from 0.216 to 2.499 kΩ/cm^(2)compared to monolithic Mg alloy.Additionally,Mg-ZnO composite with the weight loss of 0.0217 g after 28 d immersion showed lower weight loss compared to other samples with increasing immersion time.Moreover,Mg-ZnO composite with the biodegradation rate of 37.71 mm/a exhibited lower biodegradation rate compared to other samples with increasing immersion time.本研究采用搅拌摩擦法制备了添加ZnO、Ca_(2)ZnSi_(2)O_(7)、Ca_(2)MgSi_(2)O_(7)和CaSiO_(3)作为生物活性剂的镁基复合材料。在模拟体液(SBF)中研究了该复合材料的微观结构、体外生物活性、生物降解率和腐蚀行为。结果表明,在SBF中浸泡28 d,由于Ca^(2+)和PO_(4)^(3-)离子的释放,材料表面沉积了花椰菜状的羟基磷灰石(HA)晶体,证实了该材料具有良好的生物活性。此外,由于生物陶瓷粉末在Mg基体中均匀分布,超过83%的Mg基体晶粒细化,二次相颗粒均匀分布,极化电阻增加,复合材料的生物降解率较Mg基体显著降低。与镁合金相比,Mg-ZnO的极化腐蚀电阻从0.216提高到2.499 kQ/cm^(2)。此外,MgZnO复合材料在浸泡28 d后的失重0.0217 g,随着浸泡时间的延长,失重仍低于其他样品。Mg-ZnO复合材料的生物降解率为37.71 mm/a,随着浸泡时间的延长,较其他样品其生物降解率更低。

关 键 词：Mg-bioceramic bone implants friction stir processing bioactivity in vitro biodegradation BIOCORROSION 

分 类 号：TB333[一般工业技术—材料科学与工程] R318.08[医药卫生—生物医学工程]