三七提取物在抗衰老护肤品中的应用探究  

Application of Radix Notoginseng Root Extract in Anti-aging Skin Care Products

作　　者：石秀芹 吴迪 李国庆 翟文丽 安全 霍彤 SHI Xiuqin;WU Di;LI Guoqing;ZHAI Wenli;AN Quan;HUO Tong(Yunnan Baiyao Group Health Products Co.LTD,Kunming 650000,Yunnan,China;East Asian Skin Health Research Center,Beijing 100048,China;Beijing Ruier Testing Technology Co.,LTD,Beijing 100048,China)

机构地区：[1]云南白药集团健康产品有限公司,云南昆明650000 [2]东亚肌肤健康研究中心,北京100048 [3]北京睿迩检测技术有限公司,北京100048

出　　处：《中国美容医学》2024年第11期17-21,共5页Chinese Journal of Aesthetic Medicine

摘　　要：目的:研究三七提取物在化妆品中的抗衰老功效应用。方法:通过体外人皮肤成纤维细胞培养,使用H2O2和UVA刺激建立氧化应激和光老化模型,验证三七提取物的抗氧化、抗衰老功效,并进一步在人体中验证三七提取物的抗皱功效。结果:三七提取物能通过显著降低细胞内ROS和MDA含量、促进CAT酶活性,保护细胞免受H2O2引起的氧化应激损伤;同时能通过显著提高细胞中Ⅰ型胶原蛋白和透明质酸的含量,保护细胞免受UVA引起的光老化。并且面部皱纹明显的人群在使用三七提取物制备的护肤品4周后皮肤皱纹数量、皱纹深度、皱纹面积、皱纹长度得到显著改善。结论:三七提取物具有较好的抗衰老功效,在护肤品中具有较高的应用价值。Objective To study the anti-aging effect of Radix Notoginseng root extract in cosmetics.Methods In vitro human skin fibroblast culture,oxidative stress and photoaging model was established using H2O2 and UVA stimulation to verify the antioxidant and anti-aging effects of Panax Notoginseng root extract.The anti-wrinkle effect of Radix Notoginseng extract was further verified in human body.Results Panax Notoginseng root extract can significantly reduce the contents of ROS and MDA in cells,promote the activity of CAT enzyme,and protect cells from oxidative stress induced by H2O2.It also protects cells from UVA-induced photoaging by significantly increasing the content of type I collagen and hyaluronic acid in cells.In addition,the number,depth,area and length of wrinkles of the skin of people with obvious facial wrinkles were significantly improved after 4 weeks using the skin care products prepared by Radix Notoginseng root extract.Conclusion Panax Notoginseng root extract has good anti-aging effect and has high application value in skin care products.

关 键 词：三七提取物 抗衰老 抗氧化 抗皱 化妆品 

分 类 号：TQ658[化学工程—精细化工]