超皮秒激光联合微针及海藻糖皮肤屏障修复敷料治疗黄褐斑的临床观察  

Clinical Observation of Ultra Picosecond Laser Combined with Microneedle Introduction of Trehalose skin Barrier Repair Dressing in the Treatment of Melasma

作　　者：徐瑞雪 李想 鲁亚青 黄立峰 黄飞 杨莉 李雪莉 XU Ruixue;LI Xiang;LU Yaqing;HUANG Lifeng;HUANG Fei;YANG Li;LI Xueli(Department of Dermatology,Henan Provincial People's Hospital,Zhengzhou University People's Hospital,Zhengzhou 450003,Henan,China)

机构地区：[1]河南省人民医院皮肤科郑州大学人民医院,河南郑州450003

出　　处：《中国美容医学》2024年第11期36-39,共4页Chinese Journal of Aesthetic Medicine

基　　金：2022年度河南省医学科技攻关计划联合共建项目(编号:LHGJ20220015)。

摘　　要：目的:研究超皮秒激光联合滚轮微针及海藻糖皮肤屏障修复敷料治疗黄褐斑的临床有效性及安全性。方法:选取2023年2月-3月就诊于河南省人民医院的20例稳定期黄褐斑患者,给予超皮秒激光联合微针及海藻糖皮肤屏障修复敷料治疗,观察治疗前后黄褐斑的临床效果。结果:20例患者经3次联合治疗后,患者满意度为90%,治疗有效率为85%,黄褐斑面积及严重程度评分(mMASI)下降(P<0.05),皮肤病生活质量评分(Dermatology Life Quality Index,DLQI)下降(P<0.05)。治疗后经皮水分丢失明显降低(P<0.05),皮肤角质层含水量增加(P<0.05),L^(*)值升高(P<0.05),a^(*)值降低(P<0.05),b^(*)值无明显变化(P>0.05)。本研究治疗期间3例患者治疗后即刻局部红斑水肿、面部轻微疼痛,给予冷敷处理后均缓解,所有患者均未发生炎症后色素沉着、水疱等严重不良反应。结论:超皮秒激光联合微针及海藻糖皮肤屏障修复敷料治疗黄褐斑效果显著,且安全性良好。Objective To study the clinical efficacy and safety of ultra-picosecond laser combined with roller microneedle introduction of Trehalose skin barrier repair dressing in the treatment of melasma.Methods 20 patients with stable melasma treated in the author's hospital from February to March 2023,were treated with ultrar-picosecond laser combined with roller microneedle introduction of trehalose skin barrier repair dressing to observe the clinical effect of melasma.Results After 3 combined treatments,melasma area severity index(mMASI)scores were decreased(P<0.05),the patient satisfaction rate was 90%,the total effective rate was 85%,and the Dermatology Life Quality Index(DLQI)of were decreased(P<0.05).The transepidermal water loss decreased significantly(P<0.05),the skin hydration increased(P<0.05),the L*value increased(P<0.05),the a*value decreased(P<0.05),and the b*value did not change significantly(P>0.05).Conclusion The treatment of melasma by ultra-picosecond laser combined with microneedle introduction of trehalose skin barrier repair dressing has a significant clinical efficacy and good safety.

关 键 词：黄褐斑 超皮秒激光 微针 海藻糖皮肤屏障修复敷料 联合治疗 

分 类 号：R758.42[医药卫生—皮肤病学与性病学]