5-氨基酮戊酸光动力疗法联合过氧化苯甲酰凝胶治疗面部中重度痤疮疗效观察  

Impacts of 5-aminolevulinic Acid Photodynamic Therapy and Benzoyl Peroxide gel in Patients with Moderate to Severe Acne

作　　者：王恩波 张庆瑞 胡玮 WANG Enbo;ZHANG Qingrui;HU Wei(Department of Dermatology,Suzhou BOE Hospital,Suzhou 215299,Jiangsu,China)

机构地区：[1]苏州京东方医院皮肤科,江苏苏州215299

出　　处：《中国美容医学》2024年第11期48-51,共4页Chinese Journal of Aesthetic Medicine

摘　　要：目的:分析5-氨基酮戊酸光动力和过氧化苯甲酰凝胶治疗中重度痤疮患者的效果,以及对其皮损状况、皮肤屏障功能的影响。方法:选择2021年12月-2022年12月于笔者医院治疗的110例中重度痤疮患者为研究对象,随机分为观察组(55例)、对照组(55例)。对照组采用过氧化苯甲酰凝胶治疗,观察组采用5-氨基酮戊酸光动力和过氧化苯甲酰凝胶治疗。比较两组治疗后总有效率、皮损积分、皮肤屏障功能各项指标及不良反应发生情况。结果:治疗后,对照组总有效率80.00%,明显低于观察组的98.18%(P<0.05);两组患者皮损积分经过治疗均明显下降(P<0.05),且观察组低于对照组(P<0.05);两组经过治疗后角质层含水量(SCH)均上升(P<0.05),皮肤油脂、经皮水分丢失量(TEWL)、pH值均下降(P<0.05),且观察组各项皮肤屏障功能指标改善幅度大于对照组(P<0.05);两组不良反应发生率比较差异无统计学意义(P>0.05)。结论:对中重度痤疮患者采用5-氨基酮戊酸光动力+过氧化苯甲酰凝胶联合治疗,效果较为理想,临床应用价值较高。Objective To analyze the effect of 5-aminolevulinic acid photodynamic therapy combined with benzoyl peroxide gel on patients with moderate to severe acne and its impact on skin lesion condition and skin barrier function.Methods A total of 110 patients with moderate to severe acne who were treated at the author's hospital from December 2021 to December 2022 were included as study subjects and randomly assigned into an observation group(55 cases)and a control group(55 cases).The control group was treated with benzoyl peroxide gel,while the observation group received 5-aminolevulinic acid photodynamic therapy in addition to benzoyl peroxide gel.The total effective rate,skin lesion score,skin barrier function indicators,and incidence of adverse reactions were compared between the two groups after treatment.Results After treatment,the total effective rate in the control group was 80.00%,which was significantly lower than that in the observation group,which was 98.18%(P<0.05).The skin lesion score in both groups decreased significantly after treatment(P<0.05),with the observation group showing a lower score(P<0.05).After treatment,stratum corneum hydration(SCH)increased in both groups(P<0.05),while skin oil,transepidermal water loss(TEWL),and pH value decreased(P<0.05).The improvement in various skin barrier function indicators was greater in the observation group compared to the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of 5-aminolevulinic acid photodynamic therapy and benzoyl peroxide gel has an ideal effect and high clinical application value for patients with moderate to severe acne.

关 键 词：中重度痤疮 5-氨基酮戊酸光动力 过氧化苯甲酰凝胶 皮肤屏障功能 皮损 

分 类 号：R758.733[医药卫生—皮肤病学与性病学]