生物打印技术在构建血管化组织工程乳房中的应用  

Application of bioprinted vascularization for tissue-engineered breast

作　　者：苏姗姗 孙家明[1] Su Shanshan;Sun Jiaming(Department of Plastic Surgery,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China)

机构地区：[1]华中科技大学同济医学院附属协和医院整形外科,武汉430022

出　　处：《中华整形外科杂志》2024年第10期1114-1119,共6页Chinese Journal of Plastic Surgery

基　　金：国家自然科学基金(2019YFA0110500,82020108020,81873941)。

摘　　要：组织工程技术在乳腺癌术后乳房再造中有广阔的应用前景,良好的血供是保证组织长期存活的基础,也是进一步构建大体积组织工程乳房的关键。生物打印技术将传统打印技术与再生医学等概念相结合,通过使用生物墨水打印所需的具有生理功能的组织或器官,是体外构建功能性血管网络的有前景的方向。该文主要对现有的生物打印技术在构建血管化组织工程乳房方面的研究进行总结和分析,以期进一步探讨精准打印血管网络及诱导血管生成的可行性。Tissue engineering has provided wide applications in the field of breast reconstruction for breast cancer patients.A sufficient blood supply is critical to long-term tissue survival,which is also the key to creating large volume tissue-engineered breasts.Compared with traditional three-dimensional(3D)printing,3D bioprinting uses bioactive bioinks to print tissue or organ structures to bring related biofunctions.It has become a promising developing direction for recreating functional vascular networks in vitro.The article summarized the recent findings of studies on bioprinting in fabricating vascularized tissue-engineered breasts.Moreover,it has highlighted the possible mechanisms of precise bioprinting of vascular networks and angiogenesis.

关 键 词：组织工程学 生物打印技术 乳房再造 血管化 生物墨水 

分 类 号：R655.8[医药卫生—外科学] R318.08[医药卫生—临床医学]