阿普米司特联合阿维A治疗难治性毛发红糠疹1例  

Apremilast Combined with Acitretinin for the Treatment of Refractory Pityriasis Rubra Pilaris:A Case Report

作　　者：米文瑶 李萌萌[1] 张晰雯 周昱希 冯尘尘[1] 李薇[1] MI Wenyao;LI Mengmeng;ZHANG Xiwen;ZHOU Yuxi;FENG Chenchen;LI Wei(Department of Dermatology&Venereology,West China Hospital,Sichuan University,Chengdu 610000,China)

机构地区：[1]四川大学华西医院皮肤性病科,四川成都610000

出　　处：《中国皮肤性病学杂志》2024年第11期1253-1256,共4页The Chinese Journal of Dermatovenereology

基　　金：2021年度"1.3.5工程交叉学科创新项目"(ZYJC21050)。

摘　　要：患者男,62岁,前胸、双上肢红斑、鳞屑2个月,泛发全身1个月。皮肤科情况:全身片状红斑,上覆鳞屑。左前臂皮损组织病理示:局部角化不全及角化过度交替出现,基底细胞空泡化,真皮浅层小血管周围少量淋巴细胞。结合患者临床及组织病理表现,考虑诊断毛发红糠疹。阿维A单药治疗疗效不佳,加用阿普米司特治疗2个半月后皮损开始好转,近5个月皮损几乎完全消退。目前患者仍在随访中。A 62-year-old male who presented with erythema and scales on the prothorax and upper limbs for more than two months,which spread all over the body for more than one month.Physical examination found erythema covered with scales all over the patient's body.Dermatopathology of the left forearm showed local alternating dyskeratosis and hyperkeratosis,vacuolization of basal cells vacuole,and a small number of lymphocytes around small blood vessels in the superficial dermis.Pityriasis rubrum pilaris(PRP)wasdiagnosed accordingto theclinical and pathological manifestations.Acitretin monotherapy was ineffective,but the skin lesions began to improve after two and a half months of treatment after adding apremilast.The skin lesions almost completely disappeared after almost five months.The patient is still being followed up.

关 键 词：阿普米司特 阿维A 毛发红糠疹 

分 类 号：R758.69[医药卫生—皮肤病学与性病学]