天疱疮体外及动物模型研究进展  

Research Progress on in Vitro and Animal Models of Pemphigus

作　　者：李秋菊 陆家荣 郑文军[1] LI Qiuju;LU Jiarong;ZHENG Wenjun(The First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China)

机构地区：[1]广西医科大学第一附属医院,广西南宁530021

出　　处：《中国皮肤性病学杂志》2024年第11期1284-1287,共4页The Chinese Journal of Dermatovenereology

摘　　要：天疱疮(pemphigus)是一组可能致命的自身抗体介导的自身免疫性表皮内大疱性皮肤病。其发病机制尚未完全阐明,主要特征为产生抗桥粒黏附分子桥粒芯糖蛋白3(Dsg3)和桥粒芯糖蛋白1(Dsg1)的IgG。体外细胞和动物模型对研究疾病的病因、发病机制以及治疗等具有重要意义,但目前尚无统一的天疱疮体外细胞及动物模型。本文概述国内外天疱疮体外细胞和动物模型的研究进展,旨在为天疱疮的研究提供帮助。Pemphigus is a potentially life-treating autoimmune skin disease mediated by autoantibodies. These antibodies target the adhesion molecules of desmoglein 3 (Dsg3) and desmoglein 1 (Dsg1), leading to intraepidermal bullous lesions. The pathogenesis of pemphigus has not been fully elucidated. To better understand the disease, in vitro cell and animal models are of great significance for studying its etiology, pathogenesis, and potential treatments. However, no unified in vitro cell and animal models for pemphigus exist. This article provides an overview of the progress in developing these models, aiming to offer assistance for studying pemphigus.

关 键 词：天疱疮 体外细胞模型 动物模型 

分 类 号：R758.66[医药卫生—皮肤病学与性病学]