重度支气管哮喘肺部感染患者Treg和IL-9与TGF-β水平及其预测价值  

Treg and IL-9 and TGF-β in patients with severe bronchial asthma and pulmonary infection and their prediction value

作　　者：王瑞[1] 姜仁涛 刘延丽 李丛丛 WANG Rui;JIANG Ren-tao;LIU Yan-li;LI Cong-cong(Dongying Hospital of Traditional Chinese Medicine,Dongying,Shandong 257000,China)

机构地区：[1]山东中医药大学附属医院东营医院(东营市中医院)肺病科(呼吸内科),山东东营257000 [2]山东中医药大学附属医院东营医院(东营市中医院)急诊科,山东东营257000

出　　处：《中华医院感染学杂志》2024年第19期2919-2922,共4页Chinese Journal of Nosocomiology

基　　金：山东省中医药科技基金资助项目(2021Q035)。

摘　　要：目的探讨重度支气管哮喘肺部感染调节性T细胞(Treg)、白细胞介素-9(IL-9)、转化生长因子-β(TGF-β)及其预测价值。方法回顾性分析2020年6月-2023年3月山东东营市中医院收治的重度支气管哮喘患者198例的临床资料,根据肺部感染情况分为感染组(61例)和未感染组(137例);比较两组临床特点、外周血Treg、IL-9、TGF-β水平,并绘制受试者工作特征(ROC)曲线分析外周血Treg及IL-9、TGF-β联合检测对重度支气管哮喘并发肺部感染的诊断价值。结果感染组年龄、合并糖尿病比例、低蛋白血症比例及外周血Treg、血清IL-9、TGF-β高于未感染组(P<0.05);ROC曲线分析结果显示,外周血Treg及血清IL-9、TGF-β联合诊断重度支气管哮喘并发肺部感染的曲线下面积(AUC)为0.911,高于外周血Treg及血清IL-9、TGF-β单独检测(0.794、0.808、0.806,P<0.05)。结论重度支气管哮喘患者肺部感染与年龄、合并糖尿病、低蛋白血症及外周血Treg、血清IL-9、TGF-β水平偏高有关,且外周血Treg及血清IL-9、TGF-β水平联合检测对重度支气管哮喘肺部感染的诊断价值更高。OBJECTIVE To investigate regulatory T-cell(Treg),IL9,and transforming growth factor-β,in pa-tients with severe bronchial asthma and pulmonary infection and their predictive value.METHODS The clinical da-ta of 198 patients with severe bronchial asthma admitted to Dongying Hospital of Traditional Chinese Medicine in Shandong Province from June 2020 to March 2023 were retrospectively analyzed,and the patients were divided in-to the infected group(61 cases)and the uninfected group(137 cases)according to the lung infection.The clinical characteristics,peripheral blood Treg,interleukin-9(IL-9),and transforming growth factor-beta(TGF-β)levels were compared between the two groups and the diagnostic value of the combined detection of peripheral blood Treg and serum IL-9,and TGF-β for severe bronchial asthma complicating the pulmonary infection was analyzed by plotting the receiver operating characteristics(ROC)curve.RESULTS The age,proportion of combined diabetes mellitus,proportion of hypoproteinemia,and peripheral blood Treg,serum IL-9,and TGF-β in the infected group were higher than those in the uninfected group(P<0.05);the results of the ROC curve analysis showed that the area under the curve(AUC)of the combined detection of peripheral blood Treg and serum IL-9 and TGF-β for the diagnosis of severe bronchial asthma complicated with lung infection was O.91l,which was higher than that of the peripheral blood Treg and serum IL-9,TGF-β alone(0.794,0.808,0.806,P<0.05).CONCLUSION Lung infections in patients with severe bronchial asthma were associated with age,complication with diabetes mellitus,hypoproteinemia,and high levels of peripheral blood Treg,serum IL-9,and TGF-β,and the combination of peripheral blood Treg and serum IL-9,and TGF-β levels had higher value in the diagnosis of lung infections in severe bronchial asthma.

关 键 词：支气管哮喘 重度 肺部感染 调节性T细胞 白细胞介素-9 转化生长因子-β 诊断价值 

分 类 号：R563.1[医药卫生—呼吸系统]