赤藓红介导的光动力效应对甲型流感病毒的灭活效果研究  

Study on the effect of erythrosine-mediated photodynamic inactivation on influenza A viruses

作　　者：冯燕[1] 孙瑶 徐昌平[1] 高见[1] 葛琼[1] 李敏红[1] FENG Yan;SUN Yao;XU Chang-ping;GAO Jian;GE Qiong;LI Min-hong(Zhejiang Provincial Center for Disease Control and Prevention&Zhejiang Provincial Key Laboratory of Public Health Detection and Pathogenic Research,Hangzhou 310053,China;School of Pharmaceutical Sciences,Zhejiang Chinese Medical University)

机构地区：[1]浙江省疾病预防控制中心浙江省公共卫生检测与病原学研究重点实验室,浙江杭州310053 [2]浙江中医药大学药学院

出　　处：《中国消毒学杂志》2024年第10期727-730,共4页Chinese Journal of Disinfection

摘　　要：目的研究赤藓红介导的光动力效应对甲型流感病毒的灭活效果。方法采用细胞培养法,对赤藓红介导的光动力效应灭活甲型H1N1、H3N2和H9N2流感病毒的效果进行观察。结果用50μmol/L的赤藓红经蓝色LED光照5 min,对甲型H1N1、H3N2和H9N2流感病毒的平均灭活对数值依次为5.44、2.56和4.89 TCID50。赤藓红介导的光动力效应对不同材质物体表面甲型H1N1、H3N2和H9N2流感病毒灭活率依次为≥99.99%、≥99.72%和≥99.97%。结论赤藓红介导的光动力效应对甲型H1N1、H3N2和H9N2流感病毒具有良好的灭活效果。Objective To investigate the effect of erythrosine-mediated photodynamic inactivation(PDI)on influenza A virus.Methods Cell culture method was used to observe the effect of erythrosine-mediated PDI on influenza A H1N1,H3N2,and H9N2 viruses.Results 50μmol/L erythrosine was illuminated with blue LED light for 5 min,and the average inactivation logarithmic values of influenza A H1N1,H3N2,and H9N2 were 5.44,2.56,and 4.89 TCID50,respectively.The inactivation rates of erythrosine-mediated PDI on influenza A H1N1,H3N2,and H9N2 viruses on surfaces of different materials were≥99.99%,≥99.72%,and≥99.97%,respectively.Conclusion The erythrosine-mediated PDI has a good inactivation effect on influenza A H1N1,H3N2,and H9N2 viruses.

关 键 词：赤藓红 光动力效应 甲型流感病毒 灭活效果 

分 类 号：R187.1[医药卫生—流行病学] R187.4[医药卫生—公共卫生与预防医学]