短链脂肪酸在肝缺血再灌注损伤中的研究进展  

Research progress of short-chain fatty acid in liver ischemia-reperfusion injury

作　　者：徐文静 侯文 杨爽[3] 卢建森 陈德成 王菲 刘蕾[6] Xu Wenjing;Hou Wen;Yang Shuang;Lu Jiansen;Chen Decheng;Wang Fei;Liu Lei(The First Central Clinical School,Tianjin Medical University,Tianjin 300070,China;Research Institute of Transplant Medicine,Nankai University,Tianjin 300071,China;NHC Key Laboratory for Critical Care Medicine,Tianjin First Central Hospital,Tianjin 300073,China;Emergency Critical Care Center,Beijing Anzhen Hospital,Capital Medical University,Beijing 100029,China;Nankai University Medical College,Tianjin 300071,China;Department of Organ Transplantation,Tianjin First Central Hospital,Tianjin 300192,China)

机构地区：[1]天津医科大学一中心临床学院,天津300070 [2]南开大学移植医学研究院,天津300071 [3]天津市第一中心医院国家卫健委危重病急救医学重点实验室,天津300073 [4]首都医科大学附属北京安贞医院急诊危重症中心,北京100029 [5]南开大学医学院,天津300071 [6]天津市第一中心医院器官移植中心,天津300192

出　　处：《中华肝胆外科杂志》2024年第10期787-790,共4页Chinese Journal of Hepatobiliary Surgery

基　　金：天津市自然科学基金(20JCYBJC00980)。

摘　　要：肝缺血再灌注损伤(IRI)是肝移植、肝切除等外科手术后肝功能衰竭的重要原因,其发生机制与氧化应激及免疫反应密切相关,但目前仍缺乏有效的防治手段。经肠道菌群发酵产生的短链脂肪酸是人体内短链脂肪酸的主要来源,研究发现,其在氧化应激及免疫应答中扮演重要角色。本文主要介绍肠道菌群主要代谢产物短链脂肪酸在肝IRI中的研究进展,以期为肝IRI的防治策略提供参考。Liver ischemia-reperfusion injury(IRI)is a significant factor contributing to liver dysfunction following surgical procedures such as liver transplantation and hepatectomy,and its pathogenesis is closely associated with oxidative stress and immune responses.However,effective prevention and therapeutic strategies are still lacking.Short-chain fatty acids(SCFAs),primarily produced by the fermentation of gut microbiota,are the major source of these acids in the human body.Research has indicated that SCFAs play a significant role in oxidative stress and immune response.This review primarily focuses on the advancements on the role of SCFAs,the main metabolic byproducts of gut microbiota,in liver IRI,with a view to provide insights for the development of prevention and treatment strategies for liver IRI.

关 键 词：肝 缺血再灌注损伤 短链脂肪酸 氧化应激 免疫反应 

分 类 号：R657.3[医药卫生—外科学]