米诺环素联合甲硝唑棒治疗口腔种植体周围炎患者的临床研究  

Clinical trial of minocycline combined with metronidazole rod in the treatment of patients with oral peri-implantitis

作　　者：鲍士金 曹冬 姜吉铨 BAO Shi-jin;CAO Dong;JIANG Ji-quan(Department of Stomatology,Affiliated Hospital of West Anhui Health Vocational College,Lu’an 237000,Anhui Province,China)

机构地区：[1]皖西卫生职业学院附属医院口腔科,安徽六安237000

出　　处：《中国临床药理学杂志》2024年第20期3042-3046,共5页The Chinese Journal of Clinical Pharmacology

摘　　要：目的观察盐酸米诺环素软膏联合甲硝唑棒治疗对口腔种植体周围炎患者软组织炎症的影响。方法将口腔种植体周围炎患者按队列法分为对照组和试验组。2组患者均进行相同的龈上洁治、龈上刮治及局部含康复新液(每次10 mL,qd)等常规治疗,对照组在此基础上于牙周袋内放置甲硝唑棒,每2天1次;试验组在对照组治疗的基础上牙周袋内注满盐酸米诺环素软膏,每周1次;均持续用药2周。比较2组患者临床疗效、治疗前后牙周相关指标[改良菌斑指数(mPLI)、临床附着丧失(CAL)、改良龈沟出血指数(mSBI)和探诊深度(PD)]、龈沟液细胞因子[白细胞介素-6(IL-6)、IL-8、IL-1β、基质金属蛋白酶-8(MMP-8)],并进行安全性评价。结果试验组和对照组分别纳入38和42例。试验组和对照组总有效率分别为94.74%(36例/38例)和76.19%(32例/42例),在统计学上差异有统计学意义(P<0.05)。治疗后,试验组和对照组mPLI评分分别为(0.77±0.10)和(1.23±0.15)分,CAL分别为(1.18±0.16)和(2.74±0.31)mm,mSBI评分分别为(1.23±0.17)和(1.71±0.18)分,PD分别为(1.97±0.20)和(2.25±0.24)mm,IL-6分别为(2.04±0.26)和(4.01±0.42)ng·mL^(-1),IL-8分别为(4.01±0.42)和(7.00±0.73)ng·mL^(-1),IL-1β分别为(1.64±0.17)和(2.04±0.21)ng·mL^(-1),MMP-8分别为(1.02±0.14)和(1.68±0.17)ng·mL^(-1)。试验组的上述指标与对照组比较,在统计学上差异均有统计学意义(均P<0.05)。2组的药物不良反应主要有恶心呕吐、腹痛腹泻及头晕。试验组和对照组的药物不良反应总发生率为34.21%(13例/38例)和21.43%(9例/42例),在统计学上差异无统计学意义(P>0.05)。结论盐酸米诺环素软膏联合甲硝唑棒治疗口腔种植体周围炎临床有效,可有效改善牙周健康状况,显著减轻机体炎症损伤,安全性较好。Objective To observe the effect of minocycline hydrochloride ointment combined with metronidazole rod on soft tissue inflammation in patients with oral peri-implantitis.Methods Patients with oral peri-implantitis were divided into control group and treatment group according to cohort method.The patients in the two groups were treated with the same routine treatment such as supragingival scaling,supragingival scaling and local containing Kangfuxin solution(10 mL each time,qd).On this basis,the patients in the control group were placed with metronidazole rod in the periodontal pocket,once every2 days.The treatment group was filled with minocycline hydrochloride ointment in the periodontal pocket on the basis of the control group,once a week;both groups were treated for 2 weeks.The clinical efficacy,periodontal related indexes[modified plaque index(mPLI),clinical attachment loss(CAL),modified sulcus bleeding index(mSBI)and probing depth(PD)],gingival crevicular fluid cytokines[interleukin-6(IL-6),IL-8,IL-1β,matrix metalloproteinase-8(MMP-8)]before and after treatment were compared between the two groups;and the safety was evaluated.Results The treatment group and the control group were included in 38 and 42 cases,respectively.The total effective rates of the treatment group and the control group were94.74%(36 cases/38 cases)and 76.19%(32 cases/42 cases),respectively,and the difference was statistically significant(P<0.05).After treatment,the mPLI of treatment group and control group were(0.77±0.10)and(1.23±0.15)points,respectively;CAL were(1.18±0.16)and(2.74±0.31)mm,respectively;mSBI were(1.23±0.17)and(1.71±0.18)points,respectively;PD were(1.97±0.20)and(2.25±0.24)mm,respectively;IL-6 were(2.04±0.26)and(4.01±0.42)ng·mL^(-1),respectively;IL-8 were(4.01±0.42)and(7.00±0.73)ng·mL^(-1),respectively;IL-1βwere(1.64±0.17)and(2.04±4.21)ng·mL^(-1),respectively;MMP-8 were(1.02±0.14)and(1.68±0.17)ng·mL^(-1),respectively.The above indexes in the treatment group were significantly different from those in the

关 键 词：盐酸米诺环素软膏 甲硝唑棒 口腔种植体周围炎 软组织 疗效 

分 类 号：R978.1[医药卫生—药品]