Preparation and Methicillin-Resistant Staphylococcus aureus Biofilm Elimination Effect of Baicalein-Loaded Hyaluronic acid/β-Cyclodextrin grafted Chitosan Nanoparticles  

作　　者：Liting Lai Wenyou Ding Guoying Huang Mengke Wang Jinqing Chen Liuzhen Lai Xiuzhen Deng Ling Tang Xinyi Yu Ya Huang Thi Minh Hien Truong Zhongbin Zhang Wenya Ding 

机构地区：[1]Faculty of Pharmacy,Guangxi University of Traditional Chinese Medicine Key Laboratory of Common Technology of Traditional Chinese Medicine Preparation,Guangxi University of Traditional Chinese Medicine,Nanning 530200,Guangxi,China [2]College of Basic Courses,Wuhan Donghu University,Wuhan 430000,Hubei,China [3]Guangxi Engineering Research Center for Advantageous Chinese Patent Medicine and Ethnic Medicine Development,Guangxi University of Traditional Chinese Medicine,Nanning 530200,Guangxi,China

出　　处：《Biomedical and Environmental Sciences》2024年第10期1227-1231,共5页生物医学与环境科学（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.82060806);the Guangxi Natural Science Foundation Project(No.2023GXNSFAA026461);the Interdisciplinary innovation research team for key technologies of traditional Chinese medicine,emerging biological materials,and intelligent equipment development(GZKJ2303);Graduate education innovation project of Guangxi University of Chinese Medicine(YCSZ2022008);the college student innovation and entrepreneurship training program of Guangxi University of Chinese Medicine(S202310600107,202310600241,S20221060053).

摘　　要：Methicillin-resistant Staphylococcus aureus(MRSA)is a common pathogen causing acquired infections.Antibiotics are routinely employed for bacterial infection treatment.Excessive antibiotic use for bacterial infections heightens resistance,and MRSA resistance is being prevalent[1].MRSA exhibits substantial resistance to conventional antibiotics,which is associated with its biofilm-forming capability.The bacterial biofilm serves as a barrier,restricting nutrient access and slowing internal metabolism,increasing antibiotic resistance.The bacterial biofilm forms a defensive layer,resisting antibiotic penetration while preventing nutrient entry,inducing a slow bacterial metabolism,and increasing bacterial resistance[2].Consequently,biofilm formation and the emergence of resistance to conventional antibiotics have become substantial challenges in the field of infectious diseases.The development of agents to remove biofilm barriers is urgently required because biofilms are extremely hazardous.

关 键 词：metabolism ROUTINE REMOVE 

分 类 号：R318.08[医药卫生—生物医学工程]