肿瘤细胞外基质在肿瘤中的作用及治疗策略  

The role and therapeutic strategies of tumor extracellular matrix in tumors

作　　者：冯雨萌 袁诗俊 张娜 刘永军 FENG Yumeng;YUAN Shijun;ZHANG Na;LIU Yongjun(Key Laboratory of Chemical Biology Ministry of Education,School of Pharmaceutical Sciences,Shandong University,Ji'nan 250012,China)

机构地区：[1]山东大学药学院,天然产物化学生物学教育部重点实验室,济南250012

出　　处：《生命的化学》2024年第10期1806-1812,共7页Chemistry of Life

基　　金：国家自然科学基金面上项目(82373809);国家自然科学基金面上项目(82373805);山东省优秀青年基金项目(ZR2022Y076)。

摘　　要：细胞外基质(extracellular matrix,ECM)不仅为细胞提供物理支撑,还能通过适当的信号调节细胞功能,维持组织的动态平衡与稳定。ECM主要由胶原蛋白、糖蛋白等组成。ECM组成成分的变化影响着肿瘤细胞的生长、转移、免疫逃逸和耐药性的产生。ECM在肿瘤进展中具有双面作用,一方面ECM作为药物屏障和免疫抑制的摇篮,促进肿瘤的进展,另一方面又可通过限制肿瘤的转移与营养来源等方式具有抑制肿瘤效果。本文通过介绍ECM主要成分和与肿瘤的相互作用和影响,从ECM对肿瘤的促进和抑制两方面作用入手,针对ECM促瘤方面总结了靶向基质的化学降解法、靶向基质沉淀法、靶向细胞-基质相互作用的策略;针对ECM抑制肿瘤方面,总结了利用ECM限制肿瘤转移、限制营养来源、增加药物递送的策略,为肿瘤的治疗提供了新的思路。The extracellular matrix(ECM)not only provides physical support for cells,but also regulates cell function through appropriate signals to maintain the dynamic balance and stability of tissues.The ECM is mainly composed of collagen and glycoprotein,and the change of its composition affects the growth,metastasis,immune escape and drug resistance of tumor cells.ECM plays a double-sided role in tumor progression.On the one hand,ECM acts as a drug barrier and cradle of immunosuppression to promote tumor progression;On the other hand,it can inhibit tumor by restricting tumor metastasis and nutrient sources.This paper introduces the main components of ECM and its interaction and influence with tumor,and starts with the promotion and inhibition of ECM on tumor,and summarizes the strategies of targeting matrix chemical degradation,targeting matrix precipitation and targeting cell-matrix interaction for its tumor promotion.In terms of tumor inhibition by ECM,the strategies of restricting tumor metastasis,limiting nutrient sources and increasing drug delivery by ECM were summarized,which provided a new idea for tumor treatment.

关 键 词：细胞外基质 耐药性 抗肿瘤治疗 肿瘤免疫微环境 药物递送 

分 类 号：R730.2[医药卫生—肿瘤]