LncRNA在糖尿病认知功能障碍中的作用及中医药研究进展  

Research progress on the function of long non-coding RNA in diabetic cognitive dysfunction and traditional Chinese medicine

作　　者：石崯力 王忠[1] 杨卫彬[1,2] SHI Yinli;WANG Zhong;YANG Weibin(Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences,Beijing 100027,China;Graduate School of China Academy of Chinese Medical Sciences,Beijing 100027,China)

机构地区：[1]中国中医科学院中医临床基础研究所,北京100027 [2]中国中医科学院研究生院,北京100027

出　　处：《生命的化学》2024年第10期1864-1871,共8页Chemistry of Life

基　　金：国家重大科技专项重大新药开发(2017ZX09301059)。

摘　　要：糖尿病认知功能障碍(diabetic cognitive dysfunction,DCD)作为2型糖尿病常见并发症之一,目前还存在临床病情复杂、作用机制不明、治疗方案欠缺、病程持续冗长、医疗费用高昂等问题。早期、快速、准确地诊断疾病对积极有效指导临床治疗和预后康复起到关键作用。长链非编码RNA(long noncoding RNA,lncRNA)能够发挥多种生物学功能,可作为及时诊断疾病和延缓病程发展的一种新型调控标志物。它对早期准确地诊断疾病,以及指导临床治疗和预后康复起到关键性的积极作用。本文就近年来lncRNA在DCD中的作用进行综述,并结合中医药理论对DCD精准诊断及治疗的发展方向进行展望,以期寻找适用于临床的有效生物标志物和潜在中药有效成分,为后续研发相关临床实验室诊断新方法及药物提供可靠的理论基础。One of the most common complications of type 2 diabetes is diabetic cognitive dysfunction(DCD),which is characterized by complicated conditions,a dearth of effective treatment options,a low patient quality of life,and significant financial obligations.Prognostic rehabilitation and clinical treatment are greatly aided by prompt,precise,and early disease detection.Various biological functions are associated with long non-coding RNA(lncRNA).It is essential and helpful for directing therapeutic care,forecasting rehabilitation,and making a beforehand,accurate,effective diagnosis.In order to identify useful biomarkers and potentially useful components of traditional Chinese medicine that can be applied to clinical practice,as well as to provide a solid theoretical foundation for future research and development of novel diagnostic techniques and medications in relevant clinical laboratories.This work aims to explore the role of lncRNA in DCD in recent years and anticipate the future direction of accurate diagnosis and treatment of DCD,integrating traditional Chinese medicine theories.

关 键 词：长链非编码RNA 糖尿病认知功能障碍 生物标志物 中医药 治疗靶点 

分 类 号：R259[医药卫生—中西医结合] R277.7[医药卫生—中医内科学]