硫化氢介导的蛋白S-巯基化修饰在心血管病理生理中的作用  

Function of protein S-sulfhydrylation modification mediated by H_(2)S in the pathogenesis of cardiovascular diseases

作　　者：徐子航 孙许涛[1] 钟晴 张蓉 宋运佳 XU Zihang;SUN Xutao;ZHONG Qing;ZHANG Rong;SONG Yunjia(School of Basic Medical Sciences,Heilongjiang University of Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学基础医学院,哈尔滨150040

出　　处：《生命的化学》2024年第10期1914-1922,共9页Chemistry of Life

基　　金：国家自然科学基金项目(82204792);中国博士后科学基金会(2022M711089);黑龙江省博士后资助经费(LBH-Z21080);黑龙江省卫生健康委(20210202010178);黑龙江省自然科学基金项目(YQ2022H020)。

摘　　要：硫化氢(hydrogen sulfide,H_(2)S)是继一氧化氮(nitric oxide,NO)和一氧化碳(carbon monoxide,CO)之后被发现的第三种内源性气体信号分子,对心血管系统具有多种生物学作用,但内源性H_(2)S的确切治疗机制尚未阐明。目前内源性H_(2)S的作用机制是通过对靶蛋白中特定半胱氨酸残基产生S-巯基化(S-sulfhydration)作用,使其化学结构和蛋白功能发生改变。H_(2)S诱导的蛋白质S-巯基化对调控心血管系统的多种病理和生理进程具有重要影响作用。本文综述了内源性H_(2)S介导的蛋白质S-巯基化作用对心血管系统疾病的影响和潜在治疗机制。S-巯基化蛋白可能成为新的治疗靶点,这为心血管系统疾病的治疗和H_(2)S相关药物的开发提供了新的思路。Hydrogen sulfide(H_(2)S)is the third endogenous gas signaling molecule discovered after nitric oxide(NO)and carbon monoxide(CO).It has a variety of biological effects on the cardiovascular system.However,the exact therapeutic mechanism of endogenous H_(2)S has not been elucidated.At present,the mechanism of endogenous H_(2)S involves producing S-sulfhydration on specific cysteine residues in target proteins,which alters the chemical structure and function of those residues.H_(2)S-induced protein Ssulfhydration plays an important role in the regulation of various pathological and physiological processes in the cardiovascular system.This review summarizes the effects of endogenous H_(2)S-mediated protein Ssulfhydration on cardiovascular diseases and potential therapeutic mechanisms.Sulfhydrated proteins may become new therapeutic targets,which provides new ideas for the treatment of cardiovascular diseases and the development of H_(2)S-related drugs.

关 键 词：硫化氢 S-巯基化 心血管疾病 

分 类 号：R54[医药卫生—心血管疾病]