皮肤再生“星舰”:探索ADM在扩张技术中的应用突破与潜能  

“Starship”in skin regeneration:Exploring the breakthroughs and potential of acellular dermal matrix applied in skin expansion

作　　者：罗旭松[1] LUO Xusong(Department of Plastic and Reconstructive Surgery,Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200011,China)

机构地区：[1]上海交通大学医学院附属第九人民医院整复外科,上海市200011

出　　处：《组织工程与重建外科》2024年第5期503-506,共4页Journal of Tissue Engineering and Reconstructive Surgery

基　　金：国家自然科学基金(82372536);上海市自然科学基金(19ZR1430100);上海市科学技术委员会临床医学研究中心项目(22MC1940300)。

摘　　要：大面积皮肤缺损后的外观和功能同步重建仍是临床中未攻克的难题。皮肤扩张技术已广泛用于修复重建领域,但受限于较低的扩张效率、高发的并发症,以及尚未明确的作用机制,如今的皮肤扩张技术发展到了瓶颈阶段。为解决该问题,我们提出了脱细胞真皮基质辅助扩张的创新想法,并在临床上取得初步成效。脱细胞真皮基质能提供“生物友好”界面,均衡机械外力,作为活性支架可承载各类细胞,而其在皮肤扩张过程中的具体作用机制更值得深入的探究。脱细胞真皮基质作为扩张伴侣协同皮肤扩张,有望打破现有的扩张极限,进一步拓展皮肤扩张的潜能。The simultaneous reconstruction of appearance and function following large-area skin defects remains an unresolved challenge in clinical practice.Although skin expansion technology has been widely employed in tissue repair and reconstruction,its development has stagnated,primarily due to low expansion efficiency,high complication rates,and poorly understood mechanisms.To address this issue,an innovative approach utilizing acellular dermal matrix was proposed to assist in skin expansion and achieved promising preliminary clinical results.Acellular dermal matrix provides a“biocompatible”interface,balances mechanical forces,and serves as an active scaffold to support various cell types.However,its specific mechanism of action during the skin expansion process warrants further investigation.By acting as an expansion companion,acellular dermal matrix synergistically enhances skin expansion and holds the potential to break through current expansion limitations,thereby unlocking the full potential of skin expansion technology.

关 键 词：皮肤扩张 脱细胞真皮基质 真皮再生 机械牵张 

分 类 号：R622[医药卫生—整形外科]