内质网应激调控巨噬细胞免疫应答在肝脏疾病中的作用  

06The role of endoplasmic reticulum stress in regulating macrophage immune response in liver diseases

作　　者：高逸云 詹欣雨 周浩明 Gao Yiyun;Zhan Xinyu;Zhou Haoming(Department of Hepatobiliary Center,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京医科大学第一附属医院肝胆中心,南京210029

出　　处：《器官移植》2024年第6期889-894,共6页Organ Transplantation

基　　金：国家自然科学基金(82370668、82071798)。

摘　　要：内质网应激是指细胞受到刺激时产生的一种细胞应激反应,表现为在多种病理情况下内质网稳态破坏和功能紊乱,导致大量错误折叠与未折叠蛋白在内质网内累积以及钙离子失衡。巨噬细胞是肝内数量最多的免疫细胞,在维持肝脏内环境稳态和多种肝脏疾病中发挥了重要作用。最近研究证实内质网应激引起的未折叠蛋白反应在调控巨噬细胞免疫活化中扮演重要角色。本文将围绕内质网应激调控巨噬细胞免疫应答的机制,及其在肝移植缺血-再灌注损伤、肝纤维化、肝细胞癌等肝脏疾病中的作用展开综述,以加深对巨噬细胞免疫调控机制的理解,为肝脏疾病相关研究和干预治疗提供新的思路。Endoplasmic reticulum stress refers to a cellular stress response triggered when cells are stimulated,which is manifested as the disruption of endoplasmic reticulum homeostasis and dysfunction in various pathologicalconditions,resulting in the accumulation of a large number of misfolded and unfolded proteins within the endoplasmicreticulum and an imbalance of calcium ions.Macrophages are the most abundant immune cells in the liver and play animportant role in maintaining liver homeostasis and various liver diseases.Recent studies have confirmed that the unfoldedprotein response caused by endoplasmic reticulum stress plays an important role in regulating macrophage immuneresponse.This article reviews the mechanisms of endoplasmic reticulum stress regulating macrophage immune responseand its role in liver diseases such as ischemia-reperfusion injury during organ transplantation,liver fibrosis,andhepatocellular carcinoma,in order to deepen the understanding of the mechanism of macrophage immune regulation andprovide new ideas for research and interventional treatment related to liver diseases.

关 键 词：内质网应激 巨噬细胞 肝脏疾病 炎症 免疫应答 缺血-再灌注损伤 肝纤维化 肝细胞癌 

分 类 号：R617[医药卫生—外科学] R657.3[医药卫生—临床医学]