AlCl_(3)-N(CH_(2)CH_(3))_(3)·HCl离子液体中2-甲基萘乙酰基化的研究  

Acylation of 2-Methylnaphthalene in Ionic-liquid Medium AlCl_(3)-(CH_(2)CH_(3))_(3)·HCl

作　　者：冯汝明 梁春华 张仁宝 杨宏勋 凌芳 FENG Ru-ming;LIANG Chun-hua;ZHANG Ren-bao;YANG Hong-xun;LING Fang(Shanghai Our ChemBio-Technology Co.,Ltd.,Shanghai 201507,China;Sinopharm Chemical Reagent Co.,Ltd.,Shanghai 200002,China)

机构地区：[1]上海沃凯生物技术有限公司,上海201507 [2]国药集团化化学试剂有限公司,上海200002

出　　处：《化学试剂》2024年第11期121-125,共5页Chemical Reagents

摘　　要：2-甲基-6-乙酰基萘是制备2,6-萘二甲酸的重要中间体,以2-甲基萘与乙酰氯为反应物,在三氯化铝的催化作用下生成2-甲基-6-乙酰基萘。在三氯化铝-三乙胺盐酸盐离子液体中,X(AlCl_(3))=0.5时,2-甲基萘与乙酰氯之间几乎不发生反应,当X(AlCl_(3))=0.50~0.65时,随着三氯化铝含量的增加,2-甲基萘的转化率与2-甲基-6-乙酰基萘的收率均呈增加趋势。三氯化铝的含量超过0.70时,离子液体中出现固-液两相,乙酰基化反应时,反应产物中2-甲基-6-乙酰基萘的相对选择性下降。对比二氯乙烷、硝基苯、氯化铝-三乙胺盐酸盐(X(AlCl_(3))=0.5)与氯化铝-1-丁基-3-甲基咪唑氯盐(X(AlCl_(3))=0.5)为反应介质,相同的2-甲基萘与乙酰氯、三氯化铝比值下,在离子液体中均呈现更高的2-甲基-6-乙酰基萘选择性。2-Methyl-6-acylnaphthalene is an important intermediate for the synthesis of 2,6-naphthalene dicarboxylic acid.AlCl_(3) is usually used as an effective catalyst for the reaction between 2-methynaphthalene and acetyl chloride,and 2-methyl-6-acylnaphthalene is obtained.In the ionic liquid system,such as TEA-AlCl_(3),when the content of AlCl_(3) was fifty percent molar ratio,there was scarcely detectedreaction between the 2-methylnaphthalene and acetyl chloride,when the content of AlCl_(3) was located in the range of 0.50~0.65 the conversion of 2-methylnaphthalene and the yield of 2-methyl-6-acynaphthalene increased dramatically as the result of AlCl_(3) content.If the content of AlCl_(3) in the ionic liquid was beyond 0.70 there would exist two-phase in the system,however the relative selectivity of 2-methyl-6-acynaphthalene decreased.At the same molar ratio of 2-methylnaphthalene to acetyl chloride,comparing the effect of different solvents,the selectivity of 2-methyl-6-acylnaphthalenein the ionic liquid system was higher than the others.

关 键 词：乙酰氯 2-甲基萘 2-甲基-6-乙酰基萘 乙酰基化 离子液体 

分 类 号：O65[理学—分析化学]