基于数据挖掘探析明清三大中医外科医家治疗脱疽用药规律  

Based on Data mining to Explore the Three Major Chinese Surgeons in the Ming and Qing Dynasties Treatment of Anthrax Medication Rules

作　　者：高振杰 张晓丽 贾林龙 胡文龙 刘冰星 董帆 GAO Zhenjie;ZHANG Xiaoli;JIA Linlong;HU Wenlong;LIU Bingxing;DONG Fan(Shanxi University of Traditional Chinese Medicine,Taiyuan 030024,China;Affiliated Hospital of Shanxi University of Traditional Chinese,Taiyuan 030024,China)

机构地区：[1]山西中医药大学,山西太原030024 [2]山西中医药大学附属医院,山西太原030024

出　　处：《中国民族民间医药》2024年第20期113-118,共6页Chinese Journal of Ethnomedicine and Ethnopharmacy

摘　　要：目的:探讨中国古代明清时期三大著名外科代表医家对于治疗脱疽疾病的用药规律及配伍特点。方法:对明清时期中医三大医家代表著作《外科正宗》《外科证治全生集》《疡科心得集》中治疗脱疽疾病的方剂进行整理,经过标准化后。通过古今医案云平台网站对其数据进行挖掘分析所载方剂的使用、性味、归经等配伍规律和用药等特点。结果:对筛选出的41首方剂进行分析,共涉及146味中药,高频药物(>5次)共14味,主要包括当归、生甘草、肉桂、人参、白术、茯苓、没药、朱砂、黄芪、乳香、麝香、白芍、白芷、五味子。五味分析以甘味、辛味、苦味、酸味为主。四气分析以温、平、寒、微寒为主。归经分析以脾经、心经、肝经、肺经、肾经,胃经为主。功效分析以清热解毒为主,聚类分析得到主要核心药物为当归、生甘草、朱砂、没药、乳香、肉桂、茯苓、黄芪、人参、白术。药物关联分析得到关联药物组合以“乳香-没药、白芍-当归、黄芩-当归、黄芩-生甘草、熟地黄-肉桂、桔梗-生甘草”为主。复杂网络分析得到以“生甘草-当归、生甘草-朱砂、生甘草-人参、人参-当归、当归-朱砂、生甘草-雄黄、白术-当归”为主。结论:通过对上述三本著作的研究可以推断出明清时期三大医家治疗脱疽方面的用药特点以甘味、性温、归脾,清热解毒为主等,体现了明清三大医家的治疗思想与用药规律,为临床治疗脱疽提供了支持与启示,值得进一步探索与发展。Objective To explore the medication regularity and compatibility of three famous representative surgeons in treating gangrene in Ming and Qing dynasties in ancient China.Methods The prescriptions for treating gangrene in the representative works of three traditional Chinese medicine doctors in Ming and Qing dynasties,such as Surgery authentic,Surgical syndrome and treatment of whole life and Yangke Xinde Ji,were sorted out and standardized.Through the website of Cloud Platform of ancient and modern medical records,the use of its data mining analysis contained prescriptions,nature and taste,Meridian,etc.Results A total of 146 traditional Chinese medicines and 14 high frequency medicines(>GT;5 times)were involved in the analysis of 41 selected prescriptions,mainly includes angelica,raw licorice,cinnamon,ginseng,atractylodes macrocephala,Poria,myrrh,cinnabar,astragalus,frankincense,musk,Paeonia lactiflora,Angelica dahurica and Schisandra chinensis.The main five tastes were sweet,pungent,bitter and sour.The analysis of four gases is mainly temperature,flat,cold and slight cold.Meridian tropism analysis mainly focused on spleen meridian,heart meridian,liver meridian,lung meridian,kidney meridian and stomach meridian.The main drugs were Angelica sinensis,glycyrrhiza uralensis,cinnabar,myrrh,frankincense,cinnamon,poria,ginseng,Astragalus and atractylodes macrocephala by cluster analysis.Drug Association analysis showed that the major drug combinations were frankincense-myrrh,Paeonia lactiflora-angelica,scutellaria-angelica,scutellaria-raw licorice,rehmannia glutinosa-cinnamon,platycodon grandiflorum-raw licorice.Complex network analysis showed that“Raw licorice-angelica,raw licorice-cinnabar,raw licorice-ginseng,ginseng-angelica,angelica-cinnabar,raw licorice-realgar,Atractylodes macrocephala-angelica”as the main.Conclusion Through the study of the above-mentioned three books,we can infer that the characteristics of the treatment of gangrene in the Ming and Qing dynasties are sweet taste,warm nature,returning to the

关 键 词：脱疽 用药规律 方药分析 

分 类 号：R634[医药卫生—外科学]