司库奇尤单抗联合水杨酸软膏用于银屑病患者的疗效及对血清炎症细胞因子水平的影响  

Efficacy of Secukinumab Combined with Salicylic Acid Ointment in the Treatment of Psoriasis and Its Effects on Serum Inflammatory Cytokines

作　　者：张玉 侯娜 袁永革 ZHANG Yu;HOU Na;YUAN Yongge(Dept.of Dermatology,Bayingolin Mongolian Autonomous Prefecture People’s Hospital,Xinjiang Bazhou 841000,China;Dept.of Laboratory,Bayingolin Mongolian Autonomous Prefecture People’s Hospital,Xinjiang Bazhou 841000,China)

机构地区：[1]巴音郭楞蒙古自治州人民医院皮肤科,新疆巴州841000 [2]巴音郭楞蒙古自治州人民医院检验科,新疆巴州841000

出　　处：《中国医院用药评价与分析》2024年第10期1200-1203,1207,共5页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：新疆维吾尔自治区自然科学基金资助项目(No.2021D01C427)。

摘　　要：目的:探讨司库奇尤单抗联合水杨酸软膏用于银屑病患者的临床疗效和安全性,以及对免疫功能、炎症因子、一氧化氮(NO)相关指标、皮损严重程度及生活质量的影响。方法:选取2022年1月至2023年2月就诊于该院的斑块状银屑病患者82例,采用随机数字表法分为常规治疗组(n=41)和单抗治疗组(n=41)。常规治疗组患者给予水杨酸软膏治疗,单抗治疗组患者在常规治疗组的基础上应用司库奇尤单抗。对比两组患者治疗前及治疗3个月后的免疫功能(T淋巴细胞亚群:CD4^(+)、CD8^(+)和CD4^(+)/CD8^(+))、炎症因子[白细胞介素(IL)2、IL-8、IL-17、IL-23和肿瘤坏死因子α(TNF-α)]及NO相关指标[NO、一氧化氮合酶(NOS)]的表达水平;对比两组患者治疗前、治疗1个月后及治疗3个月后的皮损严重程度[银屑病面积和严重程度指数(PASI)]和生活质量[皮肤病生活质量指数(DLQI)]变化;对比两组患者临床疗效和不良事件发生率的差异。结果:治疗3个月后,单抗治疗组患者CD4^(+)、CD4^(+)/CD8^(+)水平显著高于治疗前及常规治疗组,CD8^(+)水平显著低于治疗前及常规治疗组;IL-17、TNF-α水平显著低于治疗前和常规治疗组,IL-2水平显著高于治疗前和常规治疗组;NO、NOS水平显著低于治疗前和常规治疗组,上述差异均有统计学意义(P<0.05)。两组患者治疗3个月后IL-8、IL-23水平的差异无统计学意义(P>0.05)。治疗1、3个月后,单抗治疗组患者的PASI、DLQI评分显著低于治疗前和常规治疗组,差异均有统计学意义(P<0.05)。单抗治疗组患者临床总有效率为95.12%(39/41),显著高于常规治疗组的80.49%(33/41),差异有统计学意义(P<0.05)。单抗治疗组、常规治疗组患者的总不良事件发生率分别为19.51%(8/41)、17.07%(7/41),差异无统计学意义(P>0.05)。结论:在外用水杨酸软膏治疗方案基础上联合应用司库奇尤单抗能够更显著地改善银屑病患者的免疫功能,降�OBJECTIVE:To probe into the clinical efficacy and safety of secukinumab combined with salicylic acid ointment in the treatment of patients with psoriasis and its effects on immune function,inflammatory factors,nitric oxide(NO)related indicators,severity of skin lesions and quality of life.METHODS:A total of 82 patients with plaque psoriasis admitted into the hospital from Jan.2022 to Feb.2023 were extracted to be divided into the conventional treatment group(n=41)and monoclonal antibody treatment group(n=41)through random number table method.The conventional treatment group was given salicylic acid ointment,the monoclonal antibody treatment group was given secukinumab based on the conventional treatment group.The expression levels of immune function(Tlymphocyte subsets:CD4^(+),CD8^(+)and CD4^(+)/CD8^(+)),inflammatory factors[interleukin(IL)2,IL-8,IL-17,IL-23 and tumor necrosis factorα(TNF-α)]and NO-related factors[NO,nitric oxide synthase(NOS)]were compared between two groups before treatment and after 3 months of treatment;the changes of severity of skin lesions[psoriasis area and severity index(PASI)]and quality of life[dermatology life quality index(DLQI)]were compared between two groups before treatment,after 1 month and 3 months of treatment;the differences in clinical efficacy and incidences of adverse drug reactions were compared with two groups.RESULTS:After 3 months of treatment,the CD4^(+)and CD4^(+)/CD8^(+)levels were significantly higher,and the CD8^(+)levels was significantly lower in the monoclonal antibody treatment group than those before treatment and those in the conventional treatment group;the IL-17 and TNF-αlevels were significantly lower,and the IL-2 level was significantly higher in the monoclonal antibody treatment group than those before treatment and those in the conventional treatment group;the NO and NOS levels were significantly lower in the monoclonal antibody treatment group than those before treatment and those in the conventional treatment group,with statistically significant d

关 键 词：银屑病 司库奇尤单抗 水杨酸软膏 炎症因子 

分 类 号：R986[医药卫生—药品]