布地奈德吸入气雾剂联合多巴胺治疗小儿重症肺炎的疗效及对血清HMGB1、sTREM-1水平的影响  

Efficacy of Budesonide Inhalation Aerosol Combined with Dopamine in the Treatment of Severe Pneumonia in Children and Its Effects on Serum HMGB1 and sTREM-1 High Mobility Group Protein B1 and Soluble Myeloid Cell Triggering Receptor-1 Levels

作　　者：高红 刘彦霞 白瑞珍 刘梦华 张会英[4] GAO Hong;LIU Yanxia;BAI Ruizhen;LIU Menghua;ZHANG Huiying(Dept.of Pediatric Respiratory,Shijiazhuang Maternal and Child Health Hospital,Shijiazhuang 050000,China;Dept.of Pediatrics,Shijiazhuang Maternal and Child Health Hospital,Shijiazhuang 050000,China;Dept.of Fever Clinic,Shijiazhuang Maternal and Child Health Hospital,Shijiazhuang 050000,China;Dept.of Pediatrics,Hebei Xingtang County People’s Hospital,Shijiazhuang 050600,China)

机构地区：[1]石家庄市妇幼保健院小儿呼吸二科,石家庄050000 [2]石家庄市妇幼保健院儿科,石家庄050000 [3]石家庄市妇幼保健院发热门诊,石家庄050000 [4]河北省行唐县人民医院儿科,石家庄050600

出　　处：《中国医院用药评价与分析》2024年第10期1204-1207,1211,共5页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：河北省医学研究课题计划(No.20242139)。

摘　　要：目的:探讨布地奈德吸入气雾剂联合多巴胺治疗小儿重症肺炎的疗效以及对血清高迁移率族蛋白B1(HMGB1)、可溶性髓系细胞触发受体-1(sTREM-1)水平的影响。方法:将2021年5月至2023年5月石家庄市妇幼保健院收治的120例小儿重症肺炎患儿通过随机数字表法分为对照组和研究组,每组60例。对照组患儿采用盐酸多巴胺注射液治疗,研究组患儿在对照组的基础上联合布地奈德吸入气雾剂进行雾化吸入治疗。检测两组患儿治疗前后的免疫炎症因子C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)和白细胞介素6(IL-6),血氧指数动脉血氧分压(PaO_(2))、动脉二氧化碳分压(PaCO_(2))和血氧饱和度(SaO_(2)),血清HMGB1、sTREM-1水平;同时统计两组患儿治疗过程中的不良反应发生情况以及治疗效果。结果:治疗后,两组患儿的TNF-α、IL-6和CRP水平,PaCO_(2)、HMGB1和sTREM-1水平均较治疗前降低,且研究组患儿上述指标水平显著低于对照组,差异均有统计学意义(P<0.05);治疗后,两组患儿的PaO_(2)、SaO_(2)水平均较治疗前升高,且研究组患儿升高幅度更大,差异均有统计学意义(P<0.05)。治疗后,研究组患儿的总有效率为91.67%(55/60),显著高于对照组的76.67%(46/60),差异有统计学意义(P<0.05)。研究组、对照组患儿的不良反应发生率分别为8.33%(5/60)、10.00%(6/60),差异无统计学意义(P>0.05)。结论:布地奈德吸入气雾剂联合多巴胺对小儿重症肺炎的治疗效果较好,可以减轻患儿症状,增加血氧含量,减轻炎症,安全、可靠。OBJECTIVE:To probe into the efficacy of budesonide inhalation aerosol combined with dopamine in the treatment of severe pneumonia in children and its effects on serum high mobility group protein B1(HMGB1)and soluble myeloid cell triggering receptor-1(sTREM-1)levels.METHODS:A total of 120 children with severe pneumonia admitted into Shijiazhuang Maternal and Child Health Hospital our hospital from May 2021 to May 2023 were randomly divided into control group and research group by random number table method,with 60 cases in each group.The control group was treated with dopamine hydrochloride injection,while the research group was given budesonide inhalation aerosol on the basis of the control group.The immune inflammatory factors C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),blood oxygen indexes of arterial partial pressure of oxygen(PaO_(2)),arterial partial pressure of carbon dioxide(PaCO_(2))and oxyhemoglobin saturation(SaO_(2)),serum HMGB1 and sTREM-1 levels of both groups were measured before and after treatment;the incidences of adverse drug reactions during treatment and the treatment effects of both groups were calculated.RESULTS:After treatment,the inflammatory factors of TNF-α,IL-6 and CRP levels,the PaCO_(2),HMGB1 and sTREM-1 levels decreased in both groups compared with those before treatment,and the above indicators in the research group were significantly lower than those in the control group,with statistically significant differences(P<0.05).After treatment,the PaO_(2)and SaO_(2)levels increased in both groups compared with those before treatment,and the increase was greater in the research group,with statistically significant differences(P<0.05).After treatment,the total effective rate of the research group was 91.67%(55/60),significantly higher than 76.67%(46/60)of the control group,with statistically significant difference(P<0.05).The incidences of adverse drug reactions of the research group and the control group were respectively 8.33%(5/60)and 10.00%(6/60),the di

关 键 词：小儿重症肺炎 布地奈德 多巴胺 高迁移率族蛋白B1 可溶性髓系细胞触发受体-1 

分 类 号：R977.1[医药卫生—药品] R985[医药卫生—药学]