体质量指数对长方案控制性超促排卵患者新鲜和冻融胚胎移植的影响观察  

Observing the Impact of Body Mass Index on Fresh and Frozen-Thawed Embryo Transfer in Patients Undergoing Long Protocol Controlled Ovarian Hyperstimulation

作　　者：吴喆 WU Zhe(Department of Reproductive Medicine,Luoyang Maternal and Child Health Hospital,Luoyang Henan 471000,China)

机构地区：[1]洛阳市妇幼保健院生殖医学科,河南洛阳471000

出　　处：《临床研究》2024年第11期1-4,共4页Clinical Research

摘　　要：目的探究体质量指数(BMI)对长方案控制性超促排卵(COH)患者新鲜和冻融胚胎移植的影响。方法选取2022年1月至2022年12月在洛阳市妇幼保健院生殖医学科进行体外受精-胚胎移植的210例长方案COH患者作为研究对象,并根据胚胎移植方式的不同分为新鲜组(新鲜胚胎移植,n=102)与冻融组(冻融胚胎移植,n=108),每组继续按BMI大小分为低体重组(BMI<18.5 kg/m^(2))、正常体重组(18.5≤BMI<24.0 kg/m^(2))以及超重/肥胖组(BMI≥24.0 kg/m^(2))三个亚组,新鲜组记为低体重1组、正常体重1组、超重/肥胖1组,冻融组记为低体重2组、正常体重2组、超重/肥胖2组。比较新鲜组各亚组的胚胎移植情况(正常受精率、可利用胚胎率、优质胚胎率、囊胚形成率)及临床结局(临床妊娠率、流产率、活产率);冻融组在比较上述指标的同时,在胚胎移植情况中增加复苏存活率的比较。结果低体重1组与超重/肥胖1组正常受精率、可利用胚胎率、优质胚胎率、囊胚形成率均低于正常体重1组,差异均有统计学意义(P<0.05)。新鲜组三个亚组的流产率比较,差异无统计学意义(P>0.05);超重/肥胖1组临床妊娠率与活产率均低于正常体重1组,差异均有统计学意义(P<0.05)。低体重2组与超重/肥胖2组正常受精率、可利用胚胎率、优质胚胎率、囊胚形成率、复苏存活率均低于正常体重2组,差异均有统计学意义(P<0.05)。冻融组3个亚组的流产率比较,差异无统计学意义(P>0.05);超重/肥胖2组临床妊娠率与活产率均低于正常体重2组,差异均有统计学意义(P<0.05)。结论对进行长方案COH的胚胎移植患者而言,低体重、超重或肥胖均可能对其胚胎移植结果与临床结局产生不良影响,因而患者在进行胚胎移植前应积极进行体重干预,尽可能以正常BMI进行COH,提高临床妊娠与活产率。Objective To explore the impact of body mass index(BMI)on fresh and frozen-thawed embryo transfer outcomes in patients undergoing long protocol controlled ovarian hyperstimulation(COH).Methods A total of 210 patients undergoing in vitro fertilization-embryo transfer at the Department of Reproductive Medicine of Luoyang Maternal and Child Health Hospital from January 2022 to December 2022 were selected.Patients were divided into a fresh embryo transfer group(n=102)and a frozen-thawed embryo transfer group(n=108)based on the type of embryo transfer.Each group was further divided into three subgroups based on BMI:underweight(BMI<18.5 kg/m^(2)),normal weight(18.5≤BMI<24.0 kg/m^(2)),and overweight/obese(BMI≥24.0 kg/m^(2)).The fresh embryo transfer group was labeled as underweight 1,normal weight 1,and overweight/obese 1;the frozen-thawed embryo transfer group was labeled as underweight 2,normal weight 2,and overweight/obese 2.The embryo transfer outcomes(normal fertilization rate,usable embryo rate,high-quality embryo rate,and blastocyst formation rate)and clinical outcomes(clinical pregnancy rate,miscarriage rate,and live birth rate)were compared among the subgroups in the fresh embryo transfer group.In addition,the thaw survival rate was compared in the frozen-thawed embryo transfer group.Results The normal fertilization rate,usable embryo rate,high-quality embryo rate,and blastocyst formation rate in the underweight 1 and overweight/obese 1 groups were lower than those in the normal weight 1 group(P<0.05).There were no significant differences in miscarriage rates among the three subgroups in the fresh embryo transfer group(P>0.05);the clinical pregnancy rate and live birth rate in the overweight/obese 1 group were lower than those in the normal weight 1 group(P<0.05).In the frozen-thawed embryo transfer group,the normal fertilization rate,usable embryo rate,high-quality embryo rate,blastocyst formation rate,and thaw survival rate in the underweight 2 and overweight/obese 2 groups were lower than those in the no

关 键 词：控制性超促排卵 新鲜胚胎移植 冻融胚胎移植 体质量指数 

分 类 号：R711.15[医药卫生—妇产科学]