瑞马唑仑用于重度肥胖症患者全身麻醉的有效性和安全性分析  

Analysis of the Efficacy and Safety of Remimazolam in General Anesthesia for Severe Obesity Patients

作　　者：刘巍巍 LIU Weiwei(Department of Anesthesiology,First Affiliated Hospital of Henan University of Science and Technology,Luoyang Henan 471000,China)

机构地区：[1]河南科技大学第一附属医院麻醉科,河南洛阳471000

出　　处：《临床研究》2024年第11期32-35,共4页Clinical Research

摘　　要：目的研究瑞马唑仑在重度肥胖症患者全身麻醉中的应用效果。方法选取2022年1月至2023年11月在河南科技大学第一附属医院接受手术治疗的76例重度肥胖症患者作为研究对象,所有患者均行全身麻醉,按随机数字表法分为对照组(常规全身麻醉)与研究组(瑞马唑仑全身麻醉),每组各38例。比较两组围术期心率与平均动脉压变化情况、全麻诱导期不良事件发生率、手术指标及术后并发症发生率。结果入室5 min(T_(0)),两组心率与平均动脉压比较,差异无统计学意义(P>0.05);气管插管前5 min(T_(1))、插管即刻(T_(2))、插管后5 min(T_(3))、气管拔管即刻(T_(4)),研究组心率、平均动脉压均高于对照组,差异均有统计学意义(P<0.05);对照组T_(1)~T_(4)时刻的心率、平均动脉压均较T_(0)时刻显著下降,差异均有统计学意义(P<0.05)。研究组全麻诱导期不良事件发生率(2.63%)低于对照组(18.42%),差异具有统计学意义(P<0.05)。研究组意识丧失时间、双频指数降至60以下时间、拔管时间及麻醉苏醒时间均短于对照组,术中丙泊酚与瑞芬太尼使用剂量均低于对照组,差异均有统计学意义(P<0.05)。研究组术后并发症发生率(5.26%)低于对照组(21.05%),差异均有统计学意义(P<0.05)。结论在重度肥胖症患者术中应用瑞马唑仑进行全身麻醉,有助于维持其心率与血压稳定,抑制多种不良事件与术后并发症,显著改善患者的手术情况。Objective To study the application effect of remimazolam in general anesthesia for patients with severe obesity.Methods A total of 76 patients with severe obesity who underwent surgery at the First Affiliated Hospital of Henan University of Science and Technology from January 2022 to November 2023 were selected as subjects.All patients received general anesthesia and were randomly divided into a control group(routine general anesthesia,38 patients)and a study group(remimazolam general anesthesia,38 patients).The perioperative changes in heart rate and mean arterial pressure,incidence of adverse events during anesthesia induction,surgical indicators,and postoperative complication rates were compared between the two groups.Results At 5 minutes after entering the room(T_(0)),there were no significant differences in heart rate and mean arterial pressure between the two groups(P>0.05).At 5 minutes before tracheal intubation(T_(1)),immediately after intubation(T_(2)),5 minutes after intubation(T_(3)),and immediately after tracheal extubation(T_(4)),heart rate and mean arterial pressure in the study group were higher than those in the control group,with statistically significant differences(P<0.05).In the control group,heart rate and mean arterial pressure significantly decreased from T_(1) to T_(4) compared to T_(0),with statistically significant differences(P<0.05).The incidence of adverse events during anesthesia induction in the study group(2.63%)was lower than that in the control group(18.42%),with statistically significant differences(P<0.05).The study group had shorter times for loss of consciousness,time for bispectral index to drop below 60,extubation time,and anesthesia recovery time,as well as lower dosages of propofol and remifentanil during surgery,with statistically significant differences compared to the control group(P<0.05).The postoperative complication rate in the study group(5.26%)was lower than that in the control group(21.05%),with statistically significant differences(P<0.05).Conclusion The applic

关 键 词：重度肥胖症 全身麻醉 瑞马唑仑 心率 不良事件 

分 类 号：R614[医药卫生—麻醉学]