硝酸异山梨酯注射液泵入治疗老年急性心梗合并急性左心衰的疗效和安全性分析  

Analysis of the Efficacy and Safety of Isosorbide Dinitrate Injection Pump in the Treatment of Elderly Acute Myocardial Infarction Complicated with Acute Left Heart Failure

作　　者：高原 GAO Yuan(Department of Cardiovascular Medicine,First Affiliated Hospital of Henan University of Science and Technology,Luoyang Henan 471000,China)

机构地区：[1]河南科技大学第一附属医院心血管内科,河南洛阳471000

出　　处：《临床研究》2024年第11期73-76,共4页Clinical Research

摘　　要：目的结合临床相关病例,对硝酸异山梨酯注射液泵入治疗在老年急性心梗且同时存在急性左心衰中安全性及有效性开展研究。方法将2022年11月至2024年2月河南科技大学第一附属医院收治入院的102例老年急性心梗且同时患急性左心衰的患者设置为研究样本,通过奇数、偶数抽签法划分组别,奇数51例入对照组,进行常规治疗;偶数51例入研究组,在常规治疗实施的前提下进行泵入硝酸异山梨酯注射液治疗。对比治疗有效率、治疗实施前后明尼苏达心功能不全生命质量量表评分(MLHFQ)、心功能指标[心输出量(CO)、每搏输出量(SV)、左室射血分数(LVEF)]及不良反应发生率。结果研究组治疗有效率(92.16%)高于对照组(70.59%),差异具有统计学意义(P<0.05);治疗前,两组MLHFQ评分比较差异无统计学意义(P>0.05),治疗15d后,两组MLHFQ评分均低于治疗前,且研究组MLHFQ评分低于对照组,差异均有统计学意义(P<0.05);治疗前,两组各项心功能指标对比差异无统计学意义(P>0.05),治疗15d后,两组CO、SV、LVEF水平均高于治疗前,且研究组CO、SV、LVEF水平高于对照组,差异均有统计学意义(P<0.05);两组用药期间不良反应发生率对比差异无统计学意义(P>0.05)。结论泵入硝酸异山梨酯注射液联合常规治疗是应对老年急性心梗同时患急性左心衰患者较理想的用药方案,可显著改善症状与心功能,且用药安全性较高,值得应用。Objective To study the safety and effectiveness of isosorbide dinitrate injection pump therapy in elderly patients with acute myocardial infarction complicated with acute left heart failure,based on clinical cases.Methods From November 2022 to February 2024,102 elderly patients with acute myocardial infarction and acute left heart failure admitted to the First Affiliated Hospital of Henan University of Science and Technology were selected as study samples.Patients were randomly divided into groups by odd and even numbers;51 odd-numbered patients were included in the control group and received conventional treatment,while 51 even-numbered patients were included in the study group and received isosorbide dinitrate injection pump therapy in addition to conventional treatment.The treatment efficacy,Minnesota Living with Heart Failure Questionnaire(MLHFQ)scores before and after treatment,heart function indicators[cardiac output(CO),stroke volume(SV),left ventricular ejection fraction(LVEF)],and incidence of adverse reactions were compared between the two groups.Results The treatment efficacy rate in the study group(92.16%)was higher than that in the control group(70.59%),with statistically significant differences(P<0.05).Before treatment,there were no statistically significant differences in MLHFQ scores between the two groups(P>0.05).After 15 days of treatment,MLHFQ scores were lower in both groups compared to before treatment,with the study group showing lower scores than the control group(P<0.05).Before treatment,there were no statistically significant differences in heart function indicators between the two groups(P>0.05).After 15 days of treatment,CO,SV,and LVEF levels were higher in both groups compared to before treatment,with the study group showing higher levels than the control group(P<0.05).The incidence of adverse reactions during medication was not significantly different between the two groups(P>0.05).Conclusion The combination of isosorbide dinitrate injection pump therapy and conventional treatment is

关 键 词：硝酸异山梨酯注射液 老年急性心梗 急性左心衰 心功能 不良反应 

分 类 号：R542.22[医药卫生—心血管疾病]