瓜蒌皮注射液对急性心肌梗死患者PCI术后心肌功能的保护作用观察  

Observation of the Myocardial Protective Effect of Gualoupi Injection with Acute Myocardial Infarction After PCI

作　　者：韩龙 徐谭 HAN Long;XU Tan(Department of Cardiology,Xinyang Central Hospital,Xinyang Henan 464000,China)

机构地区：[1]信阳市中心医院心血管内一科,河南信阳464000

出　　处：《临床研究》2024年第11期99-102,共4页Clinical Research

摘　　要：目的探究瓜蒌皮注射液对急性心肌梗死患者经皮冠状动脉介入术(PCI)后心肌功能的保护作用。方法选取信阳市中心医院2022年1月至2022年12月期间收治的95例急性心肌梗死患者为回顾性研究对象,均实施PCI手术治疗后,根据术后用药不同将其分为对照组和观察组。对照组46例,接受双联抗血小板聚集(阿司匹林肠溶片+氢氯吡格雷片+阿托伐他汀钙片)治疗;观察组49例,接受双联抗血小板聚集治疗以及瓜蒌皮注射液治疗。比较两组心肌功能指标水平、心血管不良事件(MACE)发生率、氧化应激指标水平。结果治疗前,两组N末端B型利尿钠肽原(NT-ProBNP)、心肌肌钙蛋白I(cTnI)、血清肌酸激酶同工酶(CK-MB)峰值以及左室射血分数(LVEF)水平比较差异无统计学意义(P>0.05);治疗后,观察组LVEF水平高于对照组,NT-ProBNP、cTnI、CK-MB峰值水平均低于对照组,差异有统计学意义(P<0.05)。观察组MACE(充血性心力衰竭、心源性猝死、非致命性心肌梗死、再次血运重建)发生率(12.24%)低于对照组(34.78%),差异有统计学意义(P<0.05)。治疗前,两组总抗氧化能力(T-Aoc)、晚期糖基化终末产物(AGEs)、谷胱甘肽过氧化物酶(GSH-Px)水平比较差异无统计学意义(P>0.05);治疗后,观察组T-Aoc、GSH-Px水平高于对照组,AGEs水平低于对照组,差异有统计学意义(P<0.05)。结论急性心肌梗死患者PCI术后实施瓜蒌皮注射液联合双联抗血小板聚集治疗可以减轻机体应激反应,有效发挥心肌功能保护效果,减少MACE发生率。Objective To investigate the myocardial protective effect of Gualoupi Injection with acute myocardial infarction after percutaneous coronary intervention(PCI).Methods Ninety-five acute myocardial infarction patients treated at Xinyang Central Hospital from January 2022 to December 2022 were selected for retrospective analysis.All patients underwent PCI surgery and were divided into two groups based on postoperative medication.The control group(46 cases)received dual antiplatelet aggregation therapy(Aspirin Enteric-coated Tablets+Clopidogrel Hydrogen Sulfate Tablets+Atorvastatin Calcium Tablets),while the observation group(49 cases)received dual antiplatelet aggregation therapy combined with Gualoupi Injection.Myocardial function indicators,major adverse cardiovascular events(MACE)incidence,and oxidative stress indicator levels were compared between the two groups.Results Before treatment,there were no significant differences in N-terminal pro-Btype natriuretic peptide(NT-ProBNP),cardiac troponin I(cTnI),serum creatine kinase-MB(CK-MB)peak,and left ventricular ejection fraction(LVEF)levels between the two groups(P>0.05).After treatment,the observation group showed higher LVEF levels and lower NT-ProBNP,cTnI,and CK-MB peak levels compared to the control group(P<0.05).The incidence of MACE(congestive heart failure,sudden cardiac death,non-fatal myocardial infarction,and revascularization)was lower in the observation group(12.24%)compared to the control group(34.78%)(P<0.05).Before treatment,there were no significant differences in total antioxidant capacity(T-Aoc),advanced glycation end products(AGEs),and glutathione peroxidase(GSHPx)levels between the two groups(P>0.05).After treatment,the observation group showed higher T-Aoc and GSH-Px levels and lower AGEs levels compared to the control group(P<0.05).Conclusion The combination of Gualoupi Injection and dual antiplatelet aggregation therapy in acute myocardial infarction patients after PCI can reduce stress responses,effectively protect myocardial function,and de

关 键 词：瓜蒌皮注射液 心肌功能 PCI手术 急性心肌梗死 

分 类 号：R542.22[医药卫生—心血管疾病]