替加环素致凝血功能异常的临床回顾分析  

Clinical retrospective analysis of coagulation abnormalities caused by tigecycline

作　　者：李巧 倪敏 颜玉颖 蒋凌晨 沈甫明 LI Qiao;NI Min;YAN Yuying;JIANG Lingchen;SHEN Fuming(School of Pharmacy,Nanjing Medical University,Nanjing 211166,China;Department of Pharmacy,Shanghai Tenth People's Hospital,Shanghai 200072,China;School of Basic Medicine and Clinical Pharmacy,China Pharmaceutical University,Nanjing 211198,China)

机构地区：[1]南京医科大学药学院,南京211166 [2]上海市第十人民医院药学部,上海200072 [3]中国药科大学基础医学与临床药学学院,南京211198

出　　处：《药物流行病学杂志》2024年第10期1099-1106,共8页Chinese Journal of Pharmacoepidemiology

基　　金：国家自然科学基金青年科学基金项目(编号:82003638)。

摘　　要：目的探讨替加环素对凝血功能的影响,为临床合理使用替加环素提供参考。方法采用回顾性研究方法,收集上海市第十人民医院2019年6月至2023年12月使用替加环素的患者病历资料,对患者的基本信息、使用替加环素前后的凝血功能指标和血栓弹力图参数等数据进行统计分析。结果41例患者在使用替加环素后活化部分凝血活酶时间、凝血酶原时间、凝血酶时间较用药前均显著延长,纤维蛋白原水平明显下降,差异均有统计学意义(P<0.05)。用药后血栓弹力图的凝血因子激活时间、血凝块形成速率参数、最大切角、弹力图最大振幅以及凝血综合指数等参数与用药前相比,差异均无统计学意义(P>0.05)。结论对于使用替加环素后疑似出现凝血异常的患者,临床上应将常规凝血功能指标和血栓弹力图相结合对患者的凝血全貌进行综合评估。Objective To investigate the effect of tigecycline on coagulation function and to provide a reference for the clinical rational use of tigecycline.Methods The data of patients treated with tigecycline in Shanghai Tenth People's Hospital between June 2019 and December 2023 by retrospective analysis.Statistical analysis was performed by collecting data on patients'basic information,routine coagulation parameters and thromboelastogram(TEG)parameters before and after the use of tigecycline.Results Activated partial thromboplastin time,prothrombin time and thrombin time were prolonged and fibrinogen levels were decreased with the use of tigecycline in 41 patients,the differences were statistically significant(P<0.05).There was no significant difference in levels of coagulation factor activation time,clot formation rate parameter,maximum angle of tangency,maximum amplitude of elastography and coagulation index after treatment with tigecycline(P>0.05).Conclusion For patients with suspected coagulation abnormalities after tigecycline administration,a comprehensive assessment of coagulation should be made by combining routine coagulation indexes with TEG.

关 键 词：替加环素 凝血异常 凝血功能指标 血栓弹力图 

分 类 号：R969[医药卫生—药理学]