白鲜皮化学成分、药理作用及毒性研究进展  

Research progress on chemical constituents,pharmacological effects and toxicity of Dictamni cortex

作　　者：胡文凯 徐晓敏 蒋鑫 沃佳美雪 贾素霞 刘树民[2] 卢芳[2] HU Wenkai;XU Xiaomin;JIANG Xin;WO Jiameixue;JIA Suxia;LIU Shumin;LU Fang(Graduate School,Heilongjiang University of Chinese Medicine,Harbin 150040,China;Institute of Traditional Chinese Medicine,Heilongjiang University of Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学研究生院,哈尔滨150040 [2]黑龙江中医药大学中医药研究院,哈尔滨150040

出　　处：《药学前沿》2024年第10期252-267,共16页China Pharmacist

基　　金：国家重点研发计划中医药现代化重点专项项目(2022YFC3502104)。

摘　　要：白鲜皮是芸香科植物白鲜的根皮,是主要的入药部位,为“诸黄风痹之要药”,具有清热解毒、祛风燥湿、止痒的功效。白鲜皮中主要含有生物碱、倍半萜类、柠檬苦素、脂肪酸、挥发油、黄酮及甾体类等228个化学成分。其体内外药理活性包括抗菌活性、抗炎活性、护肝活性、保护心血管活性、杀虫活性、抗癌活性、抗过敏活性、改善胃肠活动等。有相关文献报道白鲜皮还具有潜在的肝毒性,其中白鲜碱、梣酮、柠檬苦素类化合物为潜在肝毒性成分。本文通过查阅国内外文献,从化学成分、药理作用及毒性方面对白鲜皮进行综述,以期为白鲜皮临床合理应用及相关产品开发提供理论依据。Dictamni cortex is the root bark of Rutaceae plants.It is the main medicinal part and the key drug of‘Zhuhuang Fengbi’.It has the effects of clearing heat and detoxifying,dispelling wind and drying dampness,and relieving itching.Dictamni cortex mainly contains 228 chemical components such as alkaloids,sesquiterpenes,limonoids,fatty acids,volatile oils,flavonoids,steroids,etw.Its pharmacological activities in vivo and in vitro include antibacterial activity,anti-inflammatory activity,hepatoprotective activity,cardiovascular protection activity,insecticidal activity,anticancer activity,anti-allergic activity,and improvement of gastrointestinal activity.It has been reported that Dictamni cortex also has potential hepatotoxicity,among which dictamnine,fraxinellone and limonin compounds are potential hepatotoxic components.In this paper,the chemical constituents,pharmacological effects and toxicity of Dictamni cortex are reviewed by consulting domestic and foreign literature,to provide theoretical support for the clinical rational application and related product development of Dictamni cortex.

关 键 词：白鲜皮 化学成分 药理作用 毒性 研究进展 生物碱 倍半萜类 柠檬苦素 脂肪酸 

分 类 号：R285[医药卫生—中药学]