注射用绒促性素联合地屈孕酮治疗先兆流产患者的效果  

Effects of Chorionic gonadotrophin for injection combined with Dydrogesterone in treatment of patients with threatened abortion

作　　者：王莉[1] 倪晓醒 WANG Li;NI Xiaoxing(The Second Affiliated Hospital of Nanyang Medical College,Affiliated Hospital of Traditional Chinese Medicine of Nanyang Medical College,Nanyang 473000 Henan,China)

机构地区：[1]南阳医专学高等专科学校第二附属医院南阳医学高等专科学校附属中医院,河南南阳473000

出　　处：《中国民康医学》2024年第21期68-70,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:观察注射用绒促性素联合地屈孕酮治疗先兆流产患者的效果。方法:选取2021年1月至2023年10月该院收治的70例先兆流产患者进行前瞻性研究,按照随机数字表法将其分为对照组与观察组各35例。对照组给予地屈孕酮治疗,观察组在对照组基础上联合注射用绒促性素治疗。比较两组治疗前后激素[β-人绒毛膜促性腺激素(β-HCG)、孕酮、雌二醇(E_(2))]水平、症状相关指标(阴道流血停止时间、腹痛消失时间)水平、保胎成功率和不良反应发生率。结果:治疗后,观察组β-HCG、孕酮、E_(2)水平均高于对照组,差异有统计学意义(P<0.05);观察组阴道流血停止时间、腹痛消失时间均短于对照组,差异有统计学意义(P<0.05);两组保胎成功率和不良反应发生率比较,差异均无统计学意义(P>0.05)。结论:注射用绒促性素联合地屈孕酮治疗先兆流产患者可提高激素水平,改善症状相关指标水平,效果优于单纯地屈孕酮治疗。Objective:To observe effects of Chorionic gonadotrophin for injection combined with Dydrogesterone in treatment of patients with threatened abortion.Methods:A prospective study was conducted on 70 patients with threatened abortion admitted to this hospital from January 2021 to October 2023.According to the random number table method,they were divided into control group and observation group,35 cases in each group.The control group was treated with Dydrogesterone,while the observation group was treated with Chorionic gonadotrophin for injection on the basis of that of the control group.The levels of hormones[β-human chorionic gonadotropin(β-HCG),progesterone,estradiol(E_(2))]before and after the treatment,the symptom-related indicators(vaginal bleeding stopping time,abdominal pain disappearance time),the tocolytic success rate,and the incidence of adverse reactions were compared between the two groups.Results:After the treatment,the levels ofβ-HCG,progesterone and E_(2) in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The vaginal bleeding stopping time and the abdominal pain disappearance time in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).However,there were no significant differences in the tocolytic success rate and the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Chorionic gonadotrophin for injection combined with Dydrogesterone in the treatment of the patients with threatened abortion can improve the levels of hormones and improve the levels of symptoms related indexes.Moreover,it is superior to simple Dydrogesterone treatment.

关 键 词：先兆流产 注射用绒促性素 地屈孕酮 激素 保胎成功率 不良反应 

分 类 号：R714.21[医药卫生—妇产科学]