冠心宁注射液联合常规西药治疗冠心病心绞痛PCI术后患者的效果  

Effects of Guanxinning injection combined with conventional Western medicine in treatment of patients with coronary heart disease and angina pectoris after PCI

作　　者：杨亚兵[1] 郑菲 赵飞 YANG Yabing;ZHENG Fei;ZHAO Fei(Department of Cardiology of Beijing Renhe Hospital,Beijing 102600,China)

机构地区：[1]北京市仁和医院心内科,北京102600

出　　处：《中国民康医学》2024年第21期88-90,94,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察冠心宁注射液联合常规西药治疗冠心病心绞痛经皮冠状动脉介入(PCI)术后患者的效果。方法:回顾性分析2022年1—12月该院收治的100例冠心病心绞痛PCI术后患者的临床资料,按照治疗方案不同将其分为对照组与研究组各50例。对照组采用常规西药治疗,研究组在对照组基础上增加冠心宁注射液治疗。比较两组临床疗效,治疗前后心功能指标[舒张末期室间隔厚度(IVST)、舒张期左心室后壁厚度(LVPWT)、左心室收缩末期内径(LVESD)、左心室舒张末期内径(LVEDD)、左心室射血分数(LVEF)]、炎性因子[C反应蛋白(CRP)、白细胞介素-1(IL-1)、降钙素原(PCT)]、临床症状指标[心绞痛持续时间、发作频次、6 min步行试验(6MWT)距离]水平,以及不良反应发生率。结果:研究组治疗总有效率为92.00%(46/50),高于对照组的74.00%(37/50),差异有统计学意义(P<0.05);治疗后,两组IVST、LVEDD、LVPWT、LVESD水平均低于治疗前,且研究组低于对照组,两组LVEF水平均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);两组PCT、CRP和IL-1水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组心绞痛发作持续时间均短于治疗前,且研究组短于对照组,两组心绞痛发作频次均少于治疗前,且研究组少于对照组,两组6MWT距离均长于治疗前,且研究组长于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:冠心宁注射液联合常规西药治疗冠心病心绞痛PCI术后患者可提高治疗总有效率,改善心功能指标水平和临床症状指标,以及降低炎性因子水平的效果优于常规西药治疗。Objective:To observe effects of Guanxinning injection combined with conventional Western medicine in the treatment of patients with coronary heart disease and angina pectoris after percutaneous coronary intervention(PCI).Methods:The clinical data of 100 patients with coronary heart disease and angina pectoris after PCI admitted to this hospital from January to December 2022 were retrospectively analyzed.According to different treatment options,they were divided into control group and study group,50 cases each.The control group was treated with conventional Western medicine,while the study group was treated with Guanxinning injection on the basis of that of the control group.The clinical efficacy,the levels of cardiac function indexes[interventricular septal thickness(IVST),left ventricular end-diastolic posterior wall thickness(LVPWT),left ventricular end-systolic diameter(LVESD),left ventricular end-diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF)],the inflammatory factors[C-reactive protein(CRP),interleukin-1(IL-1),procalcitonin(PCT)],and the clinical symptom indexes[duration of angina pectoris,frequency of attack,6 min walking test distance(6MWT)]before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the study group was 92.00%(46/50),which was higher than 74.00%(37/50)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of IVST,LVEDD,LVPWT and LVESD in the two groups were lower than those before the treatment,and those in the study group were lower than the control group;the LVEF levels of the two groups were higher than those before the treatment,and that in the study group was higher than that in the control group;and the differences were statistically significant(P<0.05).The levels of PCT,CRP and IL-1 in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the

关 键 词：冠心宁注射液 冠心病心绞痛 经皮冠状动脉介入术 心功能 炎性因子 

分 类 号：R541.4[医药卫生—心血管疾病]