经鼻间歇正压通气与经鼻持续气道正压通气在新生儿呼吸窘迫综合征患儿中的应用效果比较  

Comparison of application effects of nasal intermittent positive pressure ventilation and nasal continuous positive pressure ventilation in children with neonatal respiratory distress syndrome

作　　者：王军 王娟 WANG Jun;WANG Juan(Department of Neonatology of Zhumadian First People’s Hospital,Zhumadian 463000 Henan,China)

机构地区：[1]驻马店市第一人民医院新生儿科,河南驻马店463000

出　　处：《中国民康医学》2024年第21期130-133,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:比较经鼻间歇正压通气与经鼻持续气道正压通气在新生儿呼吸窘迫综合征(NRDS)患儿中的应用效果。方法:选取2021年6月至2023年6月该院收治的76例NRDS患儿进行前瞻性研究,按照随机数字表法将其分为观察组和对照组各38例。对照组予以经鼻持续气道正压通气治疗,观察组予以经鼻间歇正压通气治疗,比较两组临床指标(无创通气时间、住院时间、总用氧时间)水平,治疗前后血气分析指标[动脉血二氧化碳分压(PaCO_(2))、动脉血氧分压(PaO_(2))]水平、呼吸频率、氧合指数、转化生长因子-β1(TGF-β1)水平、高迁移率族蛋白B1(HMGB1)水平,以及并发症发生率。结果:两组无创通气时间、总用氧时间比较,差异均无统计学意义(P>0.05);观察组住院时间短于对照组,差异有统计学意义(P<0.05);治疗24 h后,两组PaO_(2)水平均高于治疗前,且观察组高于对照组,两组PaCO_(2)水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组呼吸频率均低于治疗前,且观察组低于对照组,两组氧合指数均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);两组TGF-β1和HMGB1水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组并发症发生率为10.53%(4/38),低于对照组的28.95%(11/38),差异有统计学意义(P<0.05)。结论:经鼻间歇正压通气应用于NRDS患儿可提高氧合指数,缩短住院时间,改善血气分析指标水平,降低呼吸频率、并发症发生率、TGF-β1水平和HMGB1水平,效果优于经鼻持续气道正压通气治疗。Objective:To compare application effects of nasal intermittent positive pressure ventilation and nasal continuous positive pressure ventilation in children with neonatal respiratory distress syndrome(NRDS).Methods:A prospective study was conducted on 76 children with NRDS admitted to this hospital from June 2021 to June 2023.According to the random number table method,they were divided into observation group and control group,38 cases in each group.The control group was treated with nasal continuous positive pressure ventilation,while the observation group was treated with nasal intermittent positive pressure ventilation.The levels of clinical indexes(non-invasive ventilation time,hospitalization time,total oxygen time),blood gas analysis indexes[arterial partial pressure of carbon dioxide(PaCO_(2)),arterial partial pressure of oxygen(PaO_(2))],respiratory rate and oxygenation indexes,the transforming growth factor-β1(TGF-β1)level,the high mobility group protein B1(HMGB1)levels before and after the treatment,and the incidence of complications at 24 h after the treatment were compared between the two groups.Results:There were no significant differences in the non-invasive ventilation time and the total oxygen time between the two groups(P>0.05).The hospitalization time of the observation group was shorter than that of the control group,and the difference was statistically significant(P<0.05).After 24 hours of treatment,the PaO_(2) levels of the two groups were higher than those before the treatment,and that in the observation group was higher than that in the control group;the PaCO_(2) levels of the two groups were lower than those before the treatment,and that in the observation group was lower than that in the control group;and the differences were statistically significant(P<0.05).After 24 hours of treatment,the respiratory rate of the two groups were lower than those before the treatment,and that in the observation group was lower than that in the control group;the oxygenation index levels of the two groups

关 键 词：新生儿呼吸窘迫综合征 经鼻间歇正压通气 经鼻持续气道正压通气 血气分析 氧合指数 呼吸频率 并发症 

分 类 号：R722.1[医药卫生—儿科]