消痞汤对脾胃虚弱证慢性萎缩性胃炎患者的临床疗效  

Clinical effects of Xiaopi Decoction on patients with chronic atrophic gastritis of Spleen-Stomach Weakness Pattern

作　　者：陈硕[1] 李江辉 洪嘉辉 李素[1] 吴冬萍 陈梅芳 谢君灵 顾新月 陈少东[3] 林秋芳[4] CHEN Shuo;LI Jiang-hui;HONG Jia-hui;LI Su;WU Dong-ping;CHEN Mei-fang;XIE Jun-ling;GU Xin-yue;CHEN Shao-dong;LIN Qiu-fang(Department of Gastroenterology,Nanping Municipal People’s Hospital of Fujian,Nanping 353000,China;Graduate School of Fujian University of Traditional Chinese Medicine,Fuzhou 350108,China;College of Medicine,Xiamen University,Xiamen 361005,China;Department of Acupuncture and Moxibustion,Nanping Municipal People’s Hospital of Fujian,Nanping 353000,China)

机构地区：[1]福建省南平市人民医院消化科,福建南平353000 [2]福建中医药大学研究生院,福建福州350108 [3]厦门大学医学院,福建厦门361005 [4]福建省南平市人民医院针灸科,福建南平353000

出　　处：《中成药》2024年第10期3288-3292,共5页Chinese Traditional Patent Medicine

基　　金：福建省南平市自然科学基金项目(2019J24);2022年福建省卫生健康科技计划项目(2022QNB010)。

摘　　要：目的考察消痞汤对脾胃虚弱证慢性萎缩性胃炎患者的临床疗效。方法97例患者随机分为对照组(48例)和观察组(49例),2组均采用常规治疗,同时对照组给予枸橼酸莫沙必利片和胰酶肠溶片,观察组给予消痞汤,疗程4周。检测临床疗效、脑肠肽指标(CGRP、5-HT、SP、NPY)、Hp转阴率、胃液成分(游离酸、胃蛋白酶、亚硝酸盐、总酸)、胃肠激素(GAS、MLT、SS)、胃黏膜病理评分、不良反应发生率变化。结果观察组总有效率高于对照组(P<0.05)。治疗后,2组脑肠肽指标、NPY、SS、游离酸、胃蛋白酶、总酸升高(P<0.05),MLT、亚硝酸盐、黏膜炎症和黏膜萎缩评分降低(P<0.05),以观察组更明显(P<0.05)。2组Hp转阴率、不良反应发生率比较,差异无统计学意义(P>0.05)。结论消痞汤可安全有效地缓解胃黏膜炎症和萎缩,改善胃液成分和胃肠激素,其机制可能与调节脑-肠轴有关。AIM To investigate the clinical effects of Xiaopi Decoction on patients with chronic atrophic gastritis of Spleen-Stomach Weakness Pattern.METHODS Ninety-seven patients were randomly assigned into control group(48 cases)for 4-week intervention of conventional treatment,Mosapride Citrate Tablets and Pancreatin Enteric-coated Tablets,and observation group(49 cases)for 4-week intervention of both Xiaopi Decoction and conventional treatment.The changes in clinical effects,brain-intestinal peptide indices(CGRP,5-HT,SP,NPY),Hp negative conversion rate,gastric juice components(free acid,pepsin,nitrite,total acid),gastrointestinal hormones(GAS,MLT,SS),gastric mucosa pathological scores and incidence of adverse reactions were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P<0.05).After the treatment,the two groups displayed increased brain-intestinal peptide indices,NPY,SS,free acid,pepsin,total acid(P<0.05),and decreased MLT,nitrite,.scores for mucosal inflammation and mucosal atrophy(P<0.05),especially for the observation group(P<0.05).No significant difference in incidence of adverse reactions was found between the two groups(P>0.05).CONCLUSION For the patients with chronic atrophic gastritis of Spleen-Stomach Weakness Pattern,Xiaopi Decoction can safely and effectively reduce the inflammation and atrophy of gastric mucosa,and improve gastric juice components and gastrointestinal hormones,whose mechanism may contribute to the regulation of brain-intestinal axis.

关 键 词：消痞汤 常规治疗 慢性萎缩性胃炎 脾胃虚弱 

分 类 号：R287[医药卫生—中药学]