参术健脾增食汤对小儿厌食症患者的临床疗效  

Clinical effects of Shenzhu Jianpi Zengshi Decoction on patients with infantile anorexia

作　　者：刘晓燕 崔尧 王海燕[1] 赵莉[1] 荣潇 陈英芳[1] LIU Xiao-yan;CUI Yao;WANG Hai-yan;ZHAO Li;RONG Xiao;CHEN Ying-fang(Department of Pediatrics,Hebei Provincial Hospital of Traditional Chinese Medicine,Shijiazhuang 050011,China;Hebei Provincial Key Laboratory for Integrated Traditional Chinese and Western Medicine in Gastroenterology Research,Shijiazhuang 050011,China;Hebei Provincial Technology Innovation Center for Traditional Chinese Medicine in Treating Spleen and Kidney Diseases,Shijiazhuang 050011,China;Hebei University of Chinese Medicine,Shijiazhuang 050000,China)

机构地区：[1]河北省中医院儿科,河北石家庄050011 [2]河北省中西医结合胃肠病研究重点实验室,河北石家庄050011 [3]河北省脾肾病证中医治疗技术创新中心,河北石家庄050011 [4]河北中医药大学,河北石家庄050000

出　　处：《中成药》2024年第10期3293-3297,共5页Chinese Traditional Patent Medicine

基　　金：河北省中医药管理局科研计划项目(2023046)。

摘　　要：目的考察参术健脾增食汤对小儿厌食症患者的临床疗效。方法176例患者随机分为对照组和观察组,每组88例,对照组给予复方胃蛋白酶颗粒,观察组在对照组基础上加用参术健脾增食汤,疗程21 d。检测临床疗效、中医证候评分、小儿生长和营养状况指标(身高、体质量、BMI、进食量、血红蛋白、CD4^(+)、CD8^(+))、食欲调节因子(瘦素、血管活性肽、胃动素、胃泌素、促人生长激素释放肽)、不良反应发生率、复发率变化。结果观察组总有效率高于对照组(P<0.05),复发率更低(P<0.05)。治疗后,2组中医证候评分、CD8^(+)降低(P<0.05),身高、体质量、BMI、进食量、血红蛋白、CD4^(+)、食欲调节因子升高(P<0.05),以观察组更明显(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P<0.05)。结论参术健脾增食汤可安全有效地缓解小儿厌食症患者临床症状,改善食欲及营养状态,降低复发率。AIM To investigate the clinical effects of Shenzhu Jianpi Zengshi Decoction on infantile anorexia.METHODS One hundred and seventy-six patients were randomly assigned into control group(88 cases)for 21-day administration of Compound Pepsin Granules,and observation group(88 cases)for 21-day administration of both Shenshu Jianpi Zengshi Decoction and Compound Pepsin Granules.The changes in clinical effects,TCM syndrome scores,infantile growth and nutritional status indices(height,body weight,BMI,food intake,hemoglobin,CD4^(+),CD8^(+)),appetite regulators(leptin,vasoactive peptide,motilin,gastrin,human growth hormone releasing peptide),incidence of adverse reactions and recurrence rate were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P<0.05),along with lower recurrence rate(P<0.05).After the treatment,the two groups displayed decreased TCM syndrome scores,CD8^(+)(P<0.05),and increased height,body weight,BMI,food intake,hemoglobin,CD4^(+),appetite regulators(P<0.05),especially for the observation group(P<0.05).No significant difference in incidence of adverse reactions was found between the two groups(P>0.05).CONCLUSION For the patients with infantile anorexia,Shenzhu Jianpi Zengshi Decoction can safely and effectively alleviate clinical symptoms,improve appetite and nutritional status,and reduce recurrence rate.

关 键 词：参术健脾增食汤 复方胃蛋白酶颗粒 小儿厌食症 

分 类 号：R287[医药卫生—中药学]