Photochemical Radical Cascade 6-endo Cyclization of Dienes withα-Carbonyl Bromides for the Synthesis of Six-Membered Benzo-Fused Lactams  

作　　者：Jia-Li Sui Yang Guo Bi-Quan Xiong Ke-Wen Tang Peng-Fei Huang Yu Liu Jin-Heng Li 

机构地区：[1]Department of Chemistry and Chemical Engineering,Hunan Institute of Science and Technology,Yueyang,Hunan 414006,China [2]State Key Laboratory Base of Eco Chemical Engineering,College of Chemical Engineering,Qingdao University of Science and Technology,Qingdao,Shandong 266042,China

出　　处：《Chinese Journal of Chemistry》2024年第19期2323-2328,共6页中国化学（英文版）

基　　金：supported by the National Natural Science Foundation of China(22078084 and 51874132);the Scientific Research Fund of Hunan Provincial Education Department(22B0674);the Science and Natural Science Foundation of Hunan Province(No.2023JJ30273 and 2023JJ40301).

摘　　要：Comprehensive Summary A novel visible-light-induced radical cascade 6-endo cyclization of dienes(N-(2-vinylphenyl)acryl amides)is developed utilizingα-carbonyl bromides as alkyl reagents.This approach affords an efficient way for synthesizing six-membered benzo-fused lactam derivatives with chemo-and regio-selectivity and good functional group tolerance.Primary,secondary,and tertiary bromides are well-compatible with this cascade cyclization reaction.

关 键 词：Visible-light-induced reaction CYCLIZATION Transition-metal-free Nitrogen heterocycles |α-Carbonyl bromides LACTAMS ALKYLATION Radicalreactions Reduction 

分 类 号：O62[理学—有机化学]