Visible-Light-Induced Domino Cyclization to Access Pyrido[2,3-d]pyrimidine-2,4-diones via a Radical-Polar Crossover Reaction  

作　　者：Wanqing Zuo Yu Cheng Zhizhen Zhu Lingling Zuo Xiao Geng Zhifang Li Lei Wang 

机构地区：[1]Advanced Research Institute and School of Pharmaceutical Sciences,Taizhou University,Jaojiang,Zhejiang,318000,China [2]College of Material Chemistry and Chemical Engineering,Key Laboratory of Organosilicon Chemistry and Material Technology,Ministry of Education,Hangzhou Normal University,Hangzhou,Zhejiang 311121,China

出　　处：《Chinese Journal of Chemistry》2024年第19期2346-2350,共5页中国化学（英文版）

基　　金：the National Natural Science Foundation of China(22071171);the Natural Science Foundation of Zhejiang Province(LZ22B020003)for financial support of this work.

摘　　要：Comprehensive Summary Catalytic and green strategies for the synthesis of privileged scaffolds are synthetically appealing.We now report a radical-polar crossover(RPC)-enabled three-component cyclization of bromodifluoroalkyls with enaminones and 6-aminouraciles via a visible-light-induced domino cyclization.The reaction exhibited a broad substrate scope(>40 examples)including complex molecules,which highlighted the utility of this strategy for the construction of a library of bioactive analogs.

关 键 词：Photocatalysis HETEROCYCLES RADICALS Bromodifluoroalkyls 6-Aminouraciles ENAMINONES 

分 类 号：O62[理学—有机化学]