潘氏细胞及其分泌的抗菌肽与肠道功能稳定和疾病的关系  

Paneth Cells and the Antimicrobial Peptides Secreted by Them:Link to Intestinal Stability and Diseases

作　　者：李梁岚 李维勤 LI Lianglan;LI Weiqin(Department of Critical Care Medicine,Nanjing Jinling Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing 210000,China)

机构地区：[1]南京大学医学院附属金陵医院重症医学科,南京210000

出　　处：《中国细胞生物学学报》2024年第10期1801-1809,共9页Chinese Journal of Cell Biology

基　　金：国家自然科学基金青年科学基金(批准号:82102275)资助的课题。

摘　　要：潘氏细胞是一类独特的分泌型肠道上皮细胞,其细胞质顶部含有丰富的颗粒,这些颗粒含有抗菌肽和生长因子等重要物质并且在宿主与微生物的相互作用中发挥着重要作用。抗菌肽可以调节微生物群的组成,防御共生菌和致病菌对黏膜的穿透,保护肠道上皮;而潘氏细胞分泌的多种因子则可以维持干细胞的生态位。潘氏细胞破坏或功能出现障碍会导致各种肠道炎症,主要与肠道菌群紊乱和肠屏障破坏相关。在多种疾病中也存在潘氏细胞的异常,异常的潘氏细胞可能与疾病的发生与进展互为因果、相互影响。该文旨在梳理潘氏细胞分泌的主要抗菌肽种类,并对与潘氏细胞关联的几种疾病进行综述。Paneth cells are a unique type of secretory intestinal epithelial cells.They possess abundant granules in their apical cytoplasm.These granules contain important substances such as antimicrobial peptides and growth factors,and play an important role in the interaction between the host and microorganisms.Antimicrobial peptides can regulate the composition of the microbiota,defend against the penetration of commensal bacteria and pathogenic bacteria into the mucosa,and protect the intestinal epithelium.The various factors secreted by Paneth cells can maintain the ecological niche of stem cells.The destroyed or dysfunction of Paneth cells can lead to various intestinal inflammations,which are primarily associated with gut microbiota dysbiosis and intestinal barrier disruption.Furthermore,abnormalities in Paneth cell function are implicated in a range of diseases,suggesting a potential causal relationship with disease onset and progression.The article aims to summarize the main types of antimicrobial peptides secreted by Paneth cells and to provide an overview of several diseases associated with Paneth cells.

关 键 词：潘氏细胞 抗菌肽 溶菌酶 防御素 肠道感染 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]