原核Ago抗噬菌体功能研究进展  

Research Progress on the Anti Phage Function of Prokaryotic Ago

作　　者：梁佳敏 甄向凯 欧阳松应 LIANG Jiamin;ZHEN Xiangkai;OUYANG Songying(College of Life Sciences,Fujian Normal University,Fuzhou 350117,China;FJNU Biomedical Research Center of South,Fuzhou 350117,China)

机构地区：[1]福建师范大学生命科学学院,福州350117 [2]南方生物医学研究中心,福州350117

出　　处：《中国细胞生物学学报》2024年第10期1831-1841,共11页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:321700145);福州市科技局(批准号:2022ZD019)资助的课题。

摘　　要：Ago(Argonaute)是一类广泛存在于各界生物的蛋白家族,真核生物中,Ago作为RNA干扰(RNA interference,RNAi)过程中沉默复合物的核心组分,是一个以小RNA分子(长度21 nt)为引导,特异性降解与之配对的RNA的核糖核酸内切酶。原核生物中存在大量原核Ago(prokaryotic Argonaute,pAgo),与真核Ago相比,pAgo的组成具有多样性,然而对pAgo的功能缺乏研究。最近研究表明占pAgo大部分的短pAgo可通过多种方式发挥抗噬菌体的功能。该文总结了近期关于原核生物短pAgo抗噬菌体功能及分子机制,对其他短pAgo的功能研究具有参考价值。Ago(Argonaute)is a protein family widely present in various organisms.In eukaryotic organisms,Ago is the core component of silencing complexes in RNAi(RNA interference)processes.It is an RNA endonuclease guided by a small RNA(21 nt in length)that specifically degrades its paired RNA.In prokaryotes,there are numerous Agos,compared to eAgo(eukaryotic Ago),pAgo(prokaryotic Ago)exhibits diversity,but there is a lack of research on its functions.Recent studies have found that short pAgo,which accounts for the majority of pAgo,can exert its anti-phage function in various ways.This article summarizes recent research regarding antiphage functios and molecular mechanisms of short pAgo,providing reference value for the functional research of other short pAgo.

关 键 词：AGO 原核Ago 真核Ago RNA干扰 抗噬菌体 

分 类 号：Q75[生物学—分子生物学]