Visible Light Catalyzed Reductive Cross-Coupling of α-CF_(3)-alkyl Bromide and Alkynyl Bromide  

作　　者：Yiqiang Tian Yi Li Chun Zhang 

机构地区：[1]Institute of Molecular Plus,Departmentof Chemistry,School of Pharmaceutical Science and Technology,Faculty of Medicine,Tianjin University,92 Weijin Road,Tianjin 300072,China

出　　处：《Chinese Journal of Chemistry》2024年第20期2479-2484,共6页中国化学（英文版）

基　　金：support was from Tianjin University(2024XJD-0062);the National Natural Science Foundation of China(No.22371203).

摘　　要：Traditional reduction coupling reactions of two bromides typically rely on transition metal catalysis.Here,we introduce the development of a visible-light catalytic direct reduction coupling reaction between α-CF_(3)-alkyl bromides and alkynyl bromides to access valuable organic frameworks.Our research confirms the excellent compatibility of this reaction with various functional groups,which could be used to modify the substrate with biologically active molecular fragments.Mechanistic investigations,including control experiments,fluorescence quenching studies,and light-switching experiments,have provided insights into the reaction mechanism.This study paves the way for the application of visible-light catalysis in diverse synthetic transformations,offering a sustainable and efficient approach to organic synthesis.

关 键 词：Visiable light catalysis C-C bond formation Reductive cross-coupling Trifluoromethyl group Alkynyl group Radicals Organohalides PHOTOCHEMISTRY 

分 类 号：O64[理学—物理化学]