基于益生菌口服药物递送系统的研究进展  

Research progress in oral delivery systems with probiotics as carriers

作　　者：李文 刘夫锋 LI Wen;LIU Fufeng(College of Biotechnology,Tianjin University of Science and Technology,Tianjin 300457,China)

机构地区：[1]天津科技大学生物工程学院,天津300457

出　　处：《微生物学报》2024年第11期4086-4105,共20页Acta Microbiologica Sinica

基　　金：国家重点研发计划(2021YFC2102700);国家自然科学基金(32272269)。

摘　　要：随着当今人们对健康的不断重视,益生菌因其安全、有益于肠道健康的特点逐渐进入人们的视野,并成为食品、医药等领域的热点。然而在口服给药方面,选择使用一种安全、方便、稳定的载体是一个难题。以益生菌为载体的口服给药系统具有优异的安全性和稳定性,同时又可以保护被递送药物通过复杂的体内环境而不受破坏。本文综述了5种常见的基于益生菌的口服药物递送方式:芽孢表面展示、酵母微胶囊、重组益生菌表达、细菌样颗粒和细菌影,并详细介绍了它们各自的结构和优缺点,为口服递送载体的开发奠定了坚实的理论基础。With the increasing emphasis on health,probiotics have garnered increasing attention due to their safe and beneficial features for intestinal health and have become a hot spot in the fields of food and medicine.In terms of oral drug delivery,it is difficult to select a safe,convenient,and stable carrier.Probiotics can be used as carriers to deliver drugs through the complex in vivo environment without damage and have excellent safety and stability. This review describes the structures, advantages, and disadvantages of five common probiotic-based oral drug delivery approaches: display on spore surface, yeast microcapsules, recombinant probiotic expression, bacterium-like particles, and bacterial ghost, aiming to provide options for the application of oral delivery carriers.

关 键 词：口服给药 益生菌 芽孢 递送载体 

分 类 号：R943[医药卫生—药剂学]