Regulatory T cells in skin regeneration and wound healing  

作　　者：Samuel Knoedler Leonard Knoedler Martin Kauke-Navarro Yuval Rinkevich Gabriel Hundeshagen Leila Harhaus Ulrich Kneser Bohdan Pomahac Dennis P.Orgill Adriana C.Panayi 

机构地区：[1]Division of Plastic Surgery,Department of Surgery,Brigham and Women’s Hospital,Harvard Medical School,Boston,MA,02115,USA [2]Division of Plastic Surgery,Department of Surgery,Yale New Haven Hospital,Yale School of Medicine,New Haven,CT,06510,USA [3]Institute of Regenerative Biology and Medicine,Helmholtz Zentrum München,Munich,85764,Germany [4]Department of Hand,Plastic and Reconstructive Surgery,Microsurgery,Burn Trauma Center,BG Trauma Center Ludwigshafen,University of Heidelberg,Ludwigshafen,67071,Germany

出　　处：《Military Medical Research》2024年第5期663-685,共23页军事医学研究（英文版）

摘　　要：As the body’s integumentary system,the skin is vulnerable to injuries.The subsequent wound healing processes aim to restore dermal and epidermal integrity and functionality.To this end,multiple tissue-resident cells and recruited immune cells cooperate to efficiently repair the injured tissue.Such temporally-and spatially-coordinated interplay necessitates tight regulation to prevent collateral damage such as overshooting immune responses and excessive inflammation.In this context,regulatory T cells(Tregs)hold a key role in balancing immune homeostasis and mediating cutaneous wound healing.A comprehensive understanding of Tregs’multifaceted field of activity may help decipher wound pathologies and,ultimately,establish new treatment modalities.Herein,we review the role of Tregs in orchestrating the regeneration of skin adnexa and catalyzing healthy wound repair.Further,we discuss how Tregs operate during fibrosis,keloidosis,and scarring.

关 键 词：Regulatory T cells(Tregs) Wound healing Wound repair Skin injury Skin regeneration 

分 类 号：R392[医药卫生—免疫学]