White-light-induced synthesis of injectable alginate-based composite hydrogels for rapid hemostasis  

作　　者：Meng-De Zhang Xing Huang Zhao Li Wei Song Yi Kong Chao Zhang Li-Ting Liang Yu-Yan Huang Ya-Xin Tan Yu Feng Qing-Hua Liu Yu-Xia Zhao Xiao-Bing Fu Sha Huang 

机构地区：[1]Research Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Department,PLA General Hospital and PLA Medical College,Beijing,100853,China [2]Key Laboratory of Photochemical Conversion and Optoelectronic Materials,Technical Institute of Physics and Chemistry,Chinese Academy of Sciences,Beijing,100190,China

出　　处：《Military Medical Research》2024年第5期785-788,共4页军事医学研究（英文版）

基　　金：National Key Research and Development Program(2022YFA1104604,2017YFC1103303);Science Fund for National Defense Distinguished Young Scholars(2022-JCJQ-ZQ-016);National Nature Science Foundation of China(32000969,82002056,92268206);Military Medical Research Projects(145AKJ260015000X,2022-JCJQ-ZD-096-00);Key Support Program for Growth Factor Research(SZYZ-TR-03).

摘　　要：Dear Editor,Timely and effective hemostasis is of great significance for reducing body damage and mortality of patients [1]. Alginate is generally considered to be an excellent hemostatic polymer-based biomaterial and has been approved by the Food and Drug Administration as Generally Recognized as Safe [2]. However, the violent crosslinking reaction and unstable structure at the wound site limit its clinical applications. Hence, we report a biocompatible and injectable composite hydrogel methacrylate alginate (Alg-AEMA)-based Eosin Y/N-phenylglycine (NPG)-initiated composite hydrogel (AEC) composed of photocrosslinkable alginate, viscosity modifiers and novel white light photoinitiator, namely Eosin Y/NPG system, for instant hemorrhage control.

关 键 词：PHOTOINITIATOR PHOTOPOLYMERIZATION ALGINATE Hydrogel HEMOSTASIS 

分 类 号：TQ427.26[化学工程] R318[医药卫生—生物医学工程]