血管细胞自噬功能失调在动脉粥样硬化发病机制中的研究进展  

Research progress on autophagy dysfunction of vascular cells in the pathogenesis of atherosclerosis

作　　者：刘润民 吴克寒 杨高伟 王钰晟 王好[1] 芮涛[1] Liu Run-Min;Wu Ke-Han;Yang Gao-Wei;Wang Yu-Sheng;Wang Hao;Rui Tao(Department of Cardiology,Affiliated People's Hospital of Jiangsu University/Zhenjiang Key Clinical Research Laboratory for Myocardial Diseases,Zhenjiang,Jiangsu 212002,China)

机构地区：[1]江苏大学附属人民医院心血管内科/镇江市心肌疾病临床医学重点实验室,江苏镇江212002

出　　处：《解放军医学杂志》2024年第10期1201-1206,共6页Medical Journal of Chinese People's Liberation Army

基　　金：国家自然科学基金(82172172);镇江市创新能力建设计划项目(SS2023010)。

摘　　要：自噬是一种基本的细胞代谢过程,通过溶酶体清除细胞中受损细胞器、蛋白质聚集体,为细胞提供能量,并维持细胞组织稳态。自噬功能受损与多种疾病的病理生理密切相关。在动脉粥样硬化(AS)的发病机制中,血管细胞的自噬功能失调参与其中,是AS形成与发展的关键机制之一。包括内皮细胞、血管平滑肌细胞及巨噬细胞在内的血管细胞的功能状态、存活或死亡均可影响斑块的形成及稳定性,从而影响AS的进展。本文综述了自噬与AS的关系,并详细阐述了在AS过程中,自噬功能失调对血管细胞功能的影响,以及线粒体自噬及炎性小体的形成在AS的发生发展过程中所起的作用,旨在为防治AS提供新的思路。Autophagy is an essential cellular metabolic process that involves clearance of damaged organelles and protein aggregates in cells through lysosomes,providing energy for cells,and maintaining cellular tissue homeostasis.Impaired autophagy is closely related to the pathophysiology of a variety of diseases.In the pathogenesis of atherosclerosis(AS),the dysfunction of autophagy of vascular cells plays a crucial role in the formation and progression of AS.The functional status,survival or death of vascular cells,including endothelial cells,vascular smooth muscle cells and macrophages,can influence the formation and stability of plaques,thereby affecting the progression of AS.This review summarizes the relationship between autophagy and AS,and details the impact of autophagy dysfunction on vascular cell function in the process of AS,as well as the role of mitophagy and inflammasome in the development of AS,aiming to provide novel insights for the prevention and treatment of AS.

关 键 词：动脉粥样硬化 线粒体自噬 心血管疾病 

分 类 号：R543.3[医药卫生—心血管疾病]