金黄色葡萄球菌群体感应、双组分系统与第二信使的调控互作研究进展  

Research progress on the interaction of quorum sensing,two-component systems and second messenger regulation in Staphylococcus aureus

作　　者：付雪婷 李雪杰 刘君彦 徐振波[1] FU Xueting;LI Xuejie;LIU Junyan;XU Zhenbo(School of Food Science and Engineering,South China University of Technology,Guangzhou 510641,China;College of Food Science and Technology,Zhongkai University of Agricultural and Engineering,Guangzhou 510225,China)

机构地区：[1]华南理工大学食品科学与工程学院,广东广州510641 [2]仲恺农业工程学院轻工食品学院,广东广州510225

出　　处：《生物加工过程》2024年第5期500-512,共13页Chinese Journal of Bioprocess Engineering

基　　金：国家自然科学基金青年科学基金(32202199);广东省自然科学基金面上项目(2023A1515012332、2024A1515010128);广东省基础与应用基础研究重大项目(2020B0301030005)。

摘　　要：金黄色葡萄球菌(简称金葡菌)是一种广泛存在且常见的食源性微生物,可引发食物中毒以及多种感染,是影响人类健康的重要病原菌。在金葡菌中存在多种复杂的调控机制如群体感应(quorum sensing,QS)与双组分系统(two-component systems,TCSs)以及第二信使。本文首先描述金黄色葡萄球菌中几种QS系统的特征及其对生物被膜形成能力、致病性和耐药性的影响;然后,总结各种TCSs在金黄色葡萄球菌中的作用,以及QS和TCSs之间的不同相互作用,还讨论第二信使的功能,包括它们分别与QS和TCSs的相互作用;最后,提出寻求QS和TCSs新型控制策略的前景,包括设计干扰QS和TCSs信号传导的药物,开发QS信号抑制剂,探索天然产物中的活性成分,以及使用纳米技术制备靶向性更强的药物。此外,本文还强调两个重要的未来研究方向:加强生物被膜控制和深入研究细菌耐药机制。Staphylococcus aureus(S.aureus),a widespread and common food-borne microorganism,can not only cause food poisoning and various infections,but also act an important pathogen affecting human health.The regulatory mechanisms of S.aureus are quite complex,with involvement of quorum sensing(QS),two-component systems(TCSs)and second messenger.In this review,we first described the characteristics of several QS systems in S.aureus and their impacts on the biofilm formation ability,pathogenicity and drug resistance.Then,we summarized the roles of various TCSs in S.aureus,as well as different interactions between QS and TCSs.The functions of second messengers were also discussed,including their interactions with QS and TCSs,respectively.In the end,we presented the outlook in pursuing novel control strategies for QS and TCSs,including designing drugs to interfere with QS and TCSs signaling,developing QS signaling inhibitors,exploring active ingredients in natural products,and preparing more targeted drugs using nanotechnology.In addition,we also highlighted two important future research directions:strengthening biofilm control and further exploring the mechanisms for bacterial drug resistance.

关 键 词：金黄色葡萄球菌 群体感应 双组分系统 第二信使 生物被膜 

分 类 号：Q939.93[生物学—微生物学] R378[医药卫生—病原生物学]