微生物的群体感应系统及其在细胞生物合成领域的研究进展  

Progress in microbial quorum sensing system and its application in cell biosynthesis

作　　者：王薪 张本有 崔方超 王当丰 李婷婷 励建荣 WANG Xin;ZHANG Benyou;CUI Fangchao;WANG Dangfeng;LI Tingting;LI Jianrong(Food Safety Key Laboratory of Liaoning Province,College of Food Science and Technology,Bohai University,Jinzhou 121013,China;College of Life Science,Dalian Nationality of University,Dalian 116600,China)

机构地区：[1]渤海大学食品科学与工程学院辽宁省食品安全重点实验室,辽宁锦州121013 [2]大连民族大学生命科学学院,辽宁大连116600

出　　处：《生物加工过程》2024年第5期529-539,共11页Chinese Journal of Bioprocess Engineering

基　　金：生物技术与资源利用教育部重点实验室开放课题(KF2024002)。

摘　　要：群体感应(quorum sensing,QS)系统能够借由对特定信号分子的浓度感知实现对相关基因的靶向调控。这种独特的调控机制使得QS系统可以实现碳通量在菌株的生长及其产物积累之间的动态分配,从而实现各种物质的合成。基于此,本文着重介绍了QS系统的主要类型及其调控机制,概述其在细胞生物合成领域的应用,并对未来群体感应在食品研究中的发展进行了展望,旨在给以QS系统为基础的新型食品相关技术的发展提供理论依据。The quorum sensing system achieves targeted regulation of related genes through sensing the concentrations of specific signal molecules.This unique regulatory mechanism enables dynamic distribution of carbon flux between strain growth and product accumulation,guiding the synthesis of various substances.Herein,we described the main types of quorum sensing and related regulatory mechanisms,and subsequently summarized its applications in the field of cell biosynthesis.Furthermore,we presented the outlook for future development of quorum sensing in food research.This review will provide a theoretical basis for the development of new food-related technologies in this field.

关 键 词：群体感应 信号分子 LuxR solos 细胞生物合成 

分 类 号：Q939.95[生物学—微生物学] Q814