KIT突变与核心结合因子急性髓系白血病患儿临床特征和预后的关系  

Relation of core-binding factor acute myeloid leukemia associated with KIT mutation in children and clinical characteristics and prognosis

作　　者：谢昕 史利欢 范朋凯 陈静[1] XIE Xin;SHI Lihuan;FAN Pengkai;CHEN Jing(Key Laboratory of Pediatric Hematology of Henan Province,the Children's Hospital of Zhengzhou University,Zhengzhou 450018,Henan,China)

机构地区：[1]郑州大学附属儿童医院,河南省小儿血液医学重点实验室,河南郑州450018

出　　处：《检验医学》2024年第10期1010-1014,共5页Laboratory Medicine

基　　金：河南省医学科技攻关计划项目(LHGJ20200616)。

摘　　要：目的 分析核心结合因子急性髓系白血病(CBF-AML)患儿KIT位点表达及其与患儿临床特征和预后的关系。方法 选取2014年2月-2022年8月郑州大学附属儿童医院初诊确诊CBF-AML患儿72例,收集其相关临床资料。根据细胞遗传学分析结果分为RUNX1-RUNX1T1组(60例)和CBFβ-MYH11组(12例);根据KIT基因突变情况分为KIT阳性组(31例)和KIT阴性组(41例)。比较KIT阳性组和KIT阴性组相关临床特征和预后差异。结果 KIT阳性组和KIT阴性组性别、年龄、初诊白细胞计数、初诊外周血和骨髓原始细胞比例、髓外白血病、第一疗程完全缓解(CR)率,以及5年无事件生存率和5年总生存率差异均无统计学意义(P>0.05)。结论 KIT突变对CBF-AML患儿临床表现和预后无明显影响。Objective To analyze the expression of core-binding factor acute myeloid leukemia(CBF-AML)associated with KIT mutation in children and its relationship with clinical characteristics and prognosis.Methods Totally,72 newly diagnosed children with CBF-AML were enrolled from the Children's Hospital of Zhengzhou University from February 2014 to August 2022,and the clinical data of 72 children with CBF-AML were collected.According to the results of cytogenetic analysis,they were classified into RUNX1-RUNX1T1 group(60 cases)and CBFβ-MYH11 group(12 cases).They were classified into KIT positive group(31 cases)and KIT negative group(41 cases)according to the KIT mutation.The clinical characteristics and prognosis of KIT positive group and KIT negative group were compared.Results There was no statistical significance in gender,age,newly diagnosed white blood cell count,proportion of newly diagnosed peripheral blood and bone marrow blast cells,extramedullary leukemia,complete remission(CR)in thefirst course of treatment,5-year event-free survival and 5-year overall survival between KIT positive and KIT negative groups(P>0.05).Conclusions KIT mutation has no significant effect on the clinical manifestations and prognosis of children with CBF-AML.

关 键 词：KIT突变 核心结合因子 急性髓系白血病 儿童 预后 

分 类 号：R446.7[医药卫生—诊断学]