Design and fabrication of smart functional hydrogel wound dressing for diabetic foot ulcer  

作　　者：Yufei Wang Dandan Hou Hui Zhao Xue Geng Xin Wu Gaobiao Li Fei Sha Zengguo Feng Zongjian Liu Lin Ye 

机构地区：[1]School of Materials Science and Engineering,Bejing Institute of Technology,Beijing 100081,China [2]SINOPEC Beijing Research Institute of Chemical Industry,Beijing 100013,China [3]Department of Vascular Surgery,Beijing Luhe Hospital,Capital Medical University,Beijing 101100,China [4]Department of Vascular Surgery,Wangjing Hospital,China Academy of Chinese Medical Sciences,Bejing 100102,China [5]Beijing Rehabilitation Hospital,Capital Medical University,Beijing 100044,China

出　　处：《Frontiers of Materials Science》2024年第3期1-18,共18页材料学前沿（英文版）

基　　金：funded by the Science and Technology Innovation Project,China Academy of Chinese Medical Sciences,clinical study on the effect of modified Bu yang Huan wu decoction combined with early anticoagulant intervention on the prevention of lower extremity deep vein thrombosis syndrome(CI2021A01905)。

摘　　要：Diabetic foot ulcer(DFU)often evolves into chronic wounds that resist healing over an extended period,sometimes necessitating amputation in severe cases.Traditional wound management approaches generally fail to control these chronic sores successfully.Thus,it arouses a huge demand in clinic for a novel wound dressing to treat DFU effectively.Hydrogel as an ideal delivery system exhibits excellent loading capacity and sustainable release behavior.It also boasts tunable physical and chemical properties adaptable to diverse biomedical scenarios,making it a suitable material for fabricating functional wound dressings to treat DFU.The hydrogel dressings are classified into hemostatic,antibacterial and anti-inflammatory,and healing-promoting hydrogel dressings by associating the pathogenesis of DFU in this paper.The design and fabrication strategies for the dressings,as well as their therapeutic effects in treating DFU,are extensively reviewed.Additionally,this paper highlights future perspectives of multifunctional hydrogel dressings in DFU treatment.This review aims to provide valuable references for material scientists to design and develop hydrogel wound dressings with enhanced capabilities for DFU treatment,and to further translate them intothe clinic inthefuture.

关 键 词：hydrogel dressing MULTIFUNCTION DESIGN FABRICATION diabetic foot ulcer 

分 类 号：R318.08[医药卫生—生物医学工程] TQ427.26[医药卫生—基础医学]