In vitro evaluation of Zn-10Mg-xHA composites with the core-shell structure  

作　　者：Zeqin Cui Qifeng Hu Jianzhong Wang Lei Zhou Xiaohu Hao Wenxian Wang Weiguo Li Weili Cheng Cheng Chang 

机构地区：[1]College of Materials Science and Engineering,Taiyuan University of Technology,Taiyuan 030024,China [2]Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering,Taiyuan 030000,China [3]State Key Laboratory of Porous Metal Materials,Northwest Institute for Non-ferrous Metal Research,Xi'an 710016,China [4]Engineering Training Center,Taiyuan University of Technology,Taiyuan 030024,China [5]Guangdong Provincial Key Laboratory of Modern Surface Engineering Technology,National Engineering Laboratory of Modern Materials Surface Engineering Technology,Institute of New Materials,Guangdong Academy of Sciences,Guangzhou 510651,China

出　　处：《Frontiers of Materials Science》2024年第3期19-33,共15页材料学前沿（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(No.52375370);the Natural Science Research General Program of Shanxi Province,China(No.202103021224048);the Shanxi Province Patent Transformation Project(No.202406019);the Shanxi-Zhejiang University New Materials and Chemical Research Institute Scientific Research Project(No.2022SXTD025).

摘　　要：Zinc-based composites represent promising materials for orthopedic implants owing to their adjustable degradation rates and excellent biocompatibility.In this study,a series of Zn-10Mg-xHA(x=0-5 wt.%)composites with the core-shell structure were prepared through spark plasma sintering,and their microstructural,mechanical,and in vitro properties were systematically evaluated.Results showed that the doped hydroxyapatite(HA)is concentrated at the outer edge of the MgZn2 shell layer.The compression strength of the Zn-1oMg HA composite gradually decreased with the increase of the HA content,while its corrosion rate decreased initially and then increased.The corrosion resistance of the composite with the addition of 1 wt.%HA was improved compared to that of Zn-10Mg-0HA.However,the further increase of the HA content beyond 1 wt.%resulted in a faster degradation of the composite.Moreover,the Zn-10Mg-1HA composite significantly enhanced the activity of Mc3T3-E1 osteoblasts.Based on such findings,it is revealed that the composite containing 1 wt.%HA exhibits superior overall properties and is anticipated to serve as a promising candidate for bone implantmaterials.

关 键 词：zinc-based composite HYDROXYAPATITE mechanical property in vitro degradationbehavior BIOCOMPATIBILITY 

分 类 号：TB33[一般工业技术—材料科学与工程]