基于数据挖掘方朝晖教授治疗气滞痰凝型甲状腺结节用药规律  

Medication rules of Professor Fang Zhaohui in treating thyroid nodules with phlegm coagulation caused by Qi stagnation based on data mining

作　　者：张雯婧 方朝晖[2] 胡子朝 路宜贤 吴征 Zhang Wenjing;Fang Zhaohui;Hu Zizhao;Lu Yixian;Wu Zheng(First School of Clinical Medicine of Anhui University of Chinese Medicine,Hefei Anhui 230012;Department of Endocrinology of the First Affiliated Hospital of Anhui University of Chinese Medicine,Hefei Anhui 230031)

机构地区：[1]安徽中医药大学第一临床医学院,安徽合肥230012 [2]安徽中医药大学第一附属医院内分泌科,安徽合肥230031

出　　处：《山西中医药大学学报》2024年第9期945-951,956,共8页Journal of Shanxi University of Chinese Medicine

基　　金：国家自然科学基金项目(81774286,81603574);方朝晖安徽省名中医工作室(2019-8-515)。

摘　　要：目的:探究方朝晖教授运用组方治疗气滞痰凝型甲状腺结节的用药规律和临证经验。方法:收集方朝晖教授采用中药方剂治疗气滞痰凝证型甲状腺结节病例189例,使用数据挖掘技术对方药数据进行药物频数分析、性味归经及功效分析、关联规则分析、聚类分析,总结核心药物和关联组合。结果:共纳入处方200个,涉及中药193味,药物使用频次2975次。茯苓、合欢皮、夏枯草、泽泻、白术、当归、远志、百合的使用频率高于30%;常用的药物功效类别为补虚药、清热药、利水渗湿药、安神药等;药味以甘味、苦味为主;药性以平性、寒性为多;归经以肝、肺、脾经为要,茯苓与泽泻、白术、猪苓、土鳖虫均具有很强的关联度。结论:方朝晖教授治疗气滞痰凝型甲状腺结节以理气化痰、利水渗湿为主,兼以补脾益肺、清热宁神、活血化瘀等治法使气行、痰消、瘀散,恢复正常生理功能。Objective:To explore the medication rules and clinical experience of Professor Fang Zhaohui in the treatment of thyroid nodules with phlegm coagulation caused by Qi stagnation by using Chinese herbal prescriptions.Methods:189 cases of thyroid nodules with phlegm coagulation caused by Qi stagnation treated by Prof.Fang Zhaohui with Chinese herbal prescriptions were collected.Data mining technology was used to carry out drug frequency analysis,nature,flavor and channel tropism analysis,efficacy analysis,association rule analysis and cluster analysis,and core drugs and associated combinations were summarized.Results:A total of 200 prescriptions were included,involving 193 kinds of Chinese herbs and 2975 drug use frequencies.The use frequencies of Fuling,Hehuanpi,Xiakucao,Zexie,Baizhu,Danggui,Yuanzhi and Baihe were higher than 30%.The commonly used drugs were deficiency-tonifying drugs,heat-clearing drugs,dampness-clearing and diuresis-promoting drugs,tranquilizing drugs,etc.The medicinal flavor was mainly sweet and bitter.The channel tropism was mainly based on liver,lung and spleen channels.Conclusion:Prof.Fang Zhaohui treats thyroid nodules with phlegm coagulation caused by Qi stagnation by regulating Qi and removing phlegm,clearing dampness and promoting diuresis,combined with invigorating spleen for benefiting lung,clearing heat and calming mind,activating blood circulation and removing blood stasis.

关 键 词：甲状腺结节 数据挖掘 理气化痰 方朝晖 气滞痰凝 用药规律 

分 类 号：R249[医药卫生—中医临床基础] R259[医药卫生—中医学]