微通道连续流制备2-氯-5-甲基吡啶的工艺研究  

Process study on the preparation of 2-chloro-5-methylpyridine by microchannel continuous flow

作　　者：王怡明 仲恩奎 高秋敏 崔向勇 张巍伟 WANG Yiming;ZHONG Enkui;GAO Qiumin;CUI Xiangyong;ZHANG Weiwei(Jiangsu Ruixiang Chemical Co.,Ltd.,Yangzhou Jiangsu 211900,China)

机构地区：[1]江苏瑞祥化工有限公司,江苏扬州211900

出　　处：《石油化工应用》2024年第10期96-100,共5页Petrochemical Industry Application

摘　　要：利用微通道连续流技术制备2-氯-5-甲基吡啶的工艺研究,在以固体光气为氯化剂,氯化剂与3-甲基吡啶氧化物混合摩尔比为1.2∶1.0,反应温度为20℃,成盐反应停留时间为15 s下得到成盐液,随后升温至30℃,通入氯化氢气体至体系压力为0.6 MPa,氯化反应停留时间为180 s,2-氯-5-甲基吡啶收率最高为93.6%,与釜式反应相比,3-甲基吡啶氧化物转化率提高了6.2%,2-氯-5-甲基吡啶的收率提高了8.8%,反应总时长缩短至195 s,体现了微通道连续流反应器优良的传质传热特点,缩短了反应时间,提高了反应效率。The study on the process of preparing 2-chloro-5-methylpyridine using microchannel continuous flow technology,with solid phosgene as the chlorinating agent,the molar ratio of chlorinating agent to 3-methylpyridine oxide was 1.2∶1.0,the reaction temperature was 20℃,the salt-forming reaction residence time was 15 s,the salt solution was obtained,then the temperature was raised to 30℃,chlorine gas was introduced until the system pressure was 0.6 MPa,the chlorination reaction residence time was 180 s,the yield of 2-chloro-5-methylpyridine was highest at 93.6%.The conversion rate of 3-methylpyridine oxide was increased by 6.2%compared with the reactor reaction,the yield of 2-chloro-5-methylpyridine was increased by 8.8%,the total reaction time was shortened to 195 s,which demonstrated the excellent mass transfer and heat transfer characteristics of the microchannel continuous flow reactor,shortened the reaction time,and improved the reaction efficiency.

关 键 词：2-氯-5-甲基吡啶 微通道技术 工艺研究 

分 类 号：O626[理学—有机化学]